| Gene Symbol | ALOX15 |
| Full Name | ALOX15 - Arachidonate 15-Lipoxygenase |
| Aliases | Arachidonate 15-Lipoxygenase |
| Chromosome | 17p13.2 |
| Protein Type | Gene |
| Target Class | Enzyme |
| Function | The enzyme contains a non-heme iron center essential for its catalytic activity and requires iron for proper folding and function. |
| Mechanism of Action | Small molecule inhibitors targeting the active site iron and substrate binding |
| Primary Expression | various tissues including: [@zhang2020] - Brain: Astrocytes, microglia, and cer |
| Druggability | Low (0.38) |
| Clinical Stage | Approved |
| Molecular Weight | ~75 kDa |
| Pathways | Allosteric Binding, Allosteric Binding Sites, Enzyme Dimers, Enzyme Monomer Subunits, Nf-Kb |
| UniProt ID | P16050 |
| GeneCards | ALOX15 |
| Human Protein Atlas | ALOX15 |
| Associated Diseases | Als, alzheimers, Cancer, Cardiovascular, Cardiovascular Diseases |
| Known Drugs/Compounds | 15_HETE, omega-3 fatty acids, omega-6 fatty acids |
| Interactions | 15-HETE, ACSL4, ALOX, ALOX12, ALOX15B, Alox15 Dimer |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | ALOX15-Driven Enzymatic Ferroptosis in AD Oligoden Astrocytic Lipoxin A4 Pathway Restoration via ALOX |
| KG Connections | 386 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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