| Severity of acute infection | Hospitalized patients, particularly those requiring ICU care, show higher rates of neurological sequelae[@huang2021] |
| Age | Older adults demonstrate increased vulnerability to persistent neurological symptoms[@peluso2022] |
| Pre-existing neurological conditions | Individuals with prior neurological disorders show exacerbated symptoms[@anand2020] |
| Female sex | Studies consistently report higher rates of Long COVID in women[@bai2022] |
| Number of acute symptoms | More severe acute illness correlates with greater post-acute burden[@carvalhoschneider2021] |
| Gastrointestinal tract | Viral RNA persists in stool samples for months[@zollner2022] |
| Brain tissue | Some studies have identified viral particles in neural tissue[@meinhardt2021] |
| Cerebrospinal fluid | Rare detections in CSF of patients with neurological symptoms[@destras2021] |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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