| Inheritance | Autosomal dominant |
| Transcription regulation | Acts as a transcriptional activator, interacting with RNA polymerase II and various transcription factors |
| Alternative splicing | Regulates the splicing of numerous neuronal transcripts through interaction with splicing factors |
| RNA transport | Facilitates transport of mRNAs to dendritic and axonal compartments |
| Translation regulation | Modulates translation at synapses |
| DNA damage response | Participates in non-homologous end joining and other DNA repair pathways |
| Stress granule formation | FUS is a key component of stress granules, cytoplasmic RNA-protein assemblies that form during cellular stress |
| Penetrance | Near complete but age-dependent |
| De novo mutations | Common, particularly for severe mutations like P525L |
| Anticipation | Not typically observed |
| Founder effects | Identified in some populations |
| N-terminal mutations | Less common, affect aggregation propensity |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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