disease 2,452 words KG: ent-dise-93f3d65f
Contents

ALS-FTD-Parkinsonism Comparison Matrix

Disease Info
ALS30-40% of familial, 5-10% of sporadic cases
FTD20-30% of familial bvFTD
Parkinsonism3-5% of cases, especially with dementia
CBS5-10% of cases
KG Connections18 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (35)

R-Loop Resolution Enhancement Therapy
Score: 0.68
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.88
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
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Related Analyses (17)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
How do non-cell autonomous effects of autophagy dysfunction
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (30)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90
TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90
cGAMP biomarker analysis in ALS patient spinal cord samples
clinical · proposed · Score: 0.85
cGAMP biomarker analysis in ALS patient spinal cord samples
exploratory · proposed · Score: 0.80

Knowledge Graph (12 edges)

33300249 increased in ent-dise-93f3d65f
30458231 could be beneficial in ent-dise-93f3d65f
39317854 increase risk of ent-dise-93f3d65f
39317854 associated with increased risk of ent-dise-93f3d65f
35767949 are selectively vulnerable in ent-dise-93f3d65f
34663413 is altered in ent-dise-93f3d65f
41752118 is increasingly seen as ent-dise-93f3d65f
34873335 causes ent-dise-93f3d65f
24369373 has an oligogenic basis with ent-dise-93f3d65f
24369373 are broadening the phenotype associated with ent-dise-93f3d65f

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