disease 2,452 words KG: ent-dise-93f3d65f
Contents

ALS-FTD-Parkinsonism Comparison Matrix

Disease Info
ALS30-40% of familial, 5-10% of sporadic cases
FTD20-30% of familial bvFTD
Parkinsonism3-5% of cases, especially with dementia
CBS5-10% of cases
KG Connections18 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (35)

CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Lysosomal Membrane Repair Enhancement
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
← Prevpg 2/2

Related Analyses (17)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
How do non-cell autonomous effects of autophagy dysfunction
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (30)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90
TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90
cGAMP biomarker analysis in ALS patient spinal cord samples
clinical · proposed · Score: 0.85
cGAMP biomarker analysis in ALS patient spinal cord samples
exploratory · proposed · Score: 0.80

Knowledge Graph (12 edges)

33300249 increased in ent-dise-93f3d65f
30458231 could be beneficial in ent-dise-93f3d65f
39317854 increase risk of ent-dise-93f3d65f
39317854 associated with increased risk of ent-dise-93f3d65f
35767949 are selectively vulnerable in ent-dise-93f3d65f
34663413 is altered in ent-dise-93f3d65f
41752118 is increasingly seen as ent-dise-93f3d65f
34873335 causes ent-dise-93f3d65f
24369373 has an oligogenic basis with ent-dise-93f3d65f
24369373 are broadening the phenotype associated with ent-dise-93f3d65f

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