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clinical 4,560 words KG: DIAN-TU-001 Trial (NCT01760005)
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DIAN-TU-001 Trial (NCT01760005)

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Related Hypotheses (10)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (8)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45

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DIAN-TU-001 Trial (NCT01760005) references TREM2

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