Exploratory experiment designed to discover new patterns targeting CHI3L1 in human patients. Primary outcome: AD progression rate
A genetic association study examining the relationship between CHI3L1 gene variants and Alzheimer's disease progression in human patients. The study focused on variants that result in decreased cerebrospinal fluid YKL-40 expression and their impact on disease progression rates. This clinical genetic analysis aimed to understand how genetic variation in CHI3L1 affects AD pathogenesis and clinical outcomes in real patients.
Genetic variant analysis in AD patient cohort with CSF YKL-40 measurements
Variants decreasing YKL-40 expression associated with slower AD progression
Significant association between CHI3L1 variants and progression rates
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