| Gene Symbol | α-Synuclein |
| Chromosome | 4q21. |
| Sensitivity | ~70-80% for distinguishing PD from healthy subjects |
| Precision | Inter-assay CV typically 5-15% |
| Standardization | WHO International Standard for alpha-synuclein in development |
| Single molecule array (Simoa) | Higher sensitivity for detecting low-abundance species |
| Electrochemiluminescence | Used in automated platforms for clinical testing |
| Mass spectrometry | Enables quantification of specific post-translational modifications |
| Lower levels in PD | Mean reduction of ~30-40% compared to healthy controls |
| Specificity | ~50-60% when compared to other neurodegenerative diseases |
| Associated Diseases | M1-like Phenotype Polarization, Parkinson's disease |
| Interactions | TNF-α |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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