Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BHB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BHB |
| Key Genes/Proteins | AMPK, AQP4, Caspase-11, Gasdermin, HSP70 |
| Related Diseases | Alzheimer's disease, Alzheimer's Disease, cerebral edema, Hutchinson-Gilford Progeria Syndrome, ischemic stroke |
| Related Pathways | glymphatic system |
graph TD
BHB[BHB]
BHB -->|downregulates| SQSTM1[SQSTM1]
BHB -->|downregulates| Progerin[Progerin]
BHB -->|activates| AMPK[AMPK]
BHB -->|suppresses| Cellular_Senescence[Cellular Senescence]
BHB -->|treats| ischemic_stroke[ischemic stroke]
BHB -->|regulates| AQP4[AQP4]
BHB -->|treats| Hutchinson_Gilford_Progeria_Sy[Hutchinson-Gilford Progeria Syndrome]
BHB -->|upregulates| LAMP2A[LAMP2A]
BHB -->|upregulates| HSP70[HSP70]
BHB -->|inhibits| NLRP3[NLRP3]
ketogenic_diet[ketogenic diet] -->|modulates| BHB| Target | Relation | Type | Str |
|---|---|---|---|
| SQSTM1 | downregulates | protein | 0.95 |
| Progerin | downregulates | protein | 0.95 |
| glymphatic system | associated_with | pathway | 0.90 |
| AMPK | activates | gene | 0.90 |
| Cellular Senescence | suppresses | process | 0.90 |
| ischemic stroke | treats | disease | 0.85 |
| cerebral edema | associated_with | disease | 0.85 |
| NLRP3 | inhibits | protein | 0.80 |
| Caspase-11 | inhibits | protein | 0.80 |
| Gasdermin | inhibits | protein | 0.80 |
| Hutchinson-Gilford Progeria Syndrome | treats | disease | 0.80 |
| AQP4 | regulates | gene | 0.80 |
| neurological deficits | associated_with | phenotype | 0.80 |
| LAMP2A | upregulates | gene | 0.80 |
| HSP70 | upregulates | protein | 0.80 |
| Alzheimer's disease | treats | disease | 0.80 |
| Alzheimer's Disease | protects_against | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 40219805 | significantly reduced | paper | 0.90 |
| 32958021 | reduces AD pathology by inhibiting | paper | 0.90 |
| ketogenic diet | modulates | drug | 0.85 |
| 40219805 | may effectively mitigate | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BHB in their description or question text
No additional research found