| Gene Symbol | 4EBP1PROTEIN |
| Function | is a critical regulator of cap-dependent translation initiation in eukaryotic cells. |
| Subcellular Localization | </strong></td><td>Cytoplasm, nucleus</td></tr> |
| Amino Acids | 118 aa |
| Thr37 and Thr46 | Primary mTOR phosphorylation sites; these priming phosphorylations create docking sites for subsequent phosphorylation |
| Ser65 | Secondary site; phosphorylation here significantly reduces eIF4E binding affinity |
| Thr70 | Tertiary site; phosphorylation further stabilizes the dissociated state |
| Ser83 and Ser101 | Additional regulatory sites involved in cell cycle-dependent regulation 5 |
| Associated Diseases | neurodegeneration |
| Interactions | MTOR |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!