SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
← Pipeline / 🧬

Hypotheses

2,376 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-c4385a075deVesicle Surface Glycan Pattern Recognition0.000.55MAPTproposed2026-04-29SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-810c1e5a5acTau-Induced Lipid Membrane Asymmetry Exploitation0.000.55MAPTproposed2026-04-29SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-f7e4ecbf7b3Tau Conformational State-Specific Nanobody Targeting0.000.55MAPTproposed2026-04-29SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-16810224092Tau Post-Translational Modification State Targeting0.000.55MAPTproposed2026-04-29SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-e52f9e63944Chaperone Co-localization Guided Delivery0.000.55HSPA1Aproposed2026-04-29SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-05624b1daeeAutophagosome Marker Hijacking Strategy0.000.55MAP1LC3Aproposed2026-04-29SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-075de316a0bGlial Scar Architecture Manipulation for Functional Compartmentalization0.000.55ARAP3, cytoskeletal regulatorsproposed2026-04-29astrocyte-subtypes
h-debate-3cd1c9d33eaNrf2-NF-κB Oscillatory Circuit Modulation0.000.55NFE2L2, NFKB1proposed2026-04-29astrocyte-subtypes
h-debate-10f2f867bbaNascent Transcript Targeting for Real-Time Reprogramming0.000.55RNA processing machineryproposed2026-04-29astrocyte-subtypes
h-debate-cfec1a7354aTemporal mTOR Modulation for Sequential A1/A2 Switching0.000.55MTORproposed2026-04-29astrocyte-subtypes
h-debate-49e9c1f5ecaCombinatorial Il-1α/TNFα/C1q Antagonism with Selective Agonism0.000.55IL1A, TNF, C1QA, NFE2L2proposed2026-04-29astrocyte-subtypes
h-debate-dfbbb1f6b9fMicroglial GLP-1R-Mediated Astrocyte Programming0.000.55GLP1R, ARAP3proposed2026-04-29astrocyte-subtypes
h-debate-698ff0b1f07Age-Stratified Astrocyte Subtype Switching0.000.55Multiple age-dependent switchesproposed2026-04-29astrocyte-subtypes
h-debate-68fd2b81578Bi-directional Transcytosis Inhibition Strategy0.000.55ABCB1 (P-glycoprotein), ABCG2 (BCRP), APP/Aβproposed2026-04-29sda-2026-04-01-gap-008
h-debate-24170addd30Intranasal Delivery of BBB-Penetrating Antibody Conjugates0.000.55APP/Aβ, olfactory receptor neuronsproposed2026-04-29sda-2026-04-01-gap-008
h-debate-477286ec859Engineered Exosome-Encapsulated Antibody Fragments0.000.55APP/Aβ, TFRC, lactoferrin receptorproposed2026-04-29sda-2026-04-01-gap-008
h-debate-a513718a3eeCell-Penetrating Peptide Conjugated Nanobodies0.000.55APP/Aβ oligomers, various CPP sequencesproposed2026-04-29sda-2026-04-01-gap-008
h-debate-72a94a5767cLRP1-Mediated Trojan Horse Delivery System0.000.55LRP1 (low-density lipoprotein receptor-related protein 1), Aproposed2026-04-29sda-2026-04-01-gap-008
h-debate-0df96d9a759Dual-Targeting BBB Shuttle-Amyloid Antibodies0.000.55TFRC (transferrin receptor), APP/Aβproposed2026-04-29sda-2026-04-01-gap-008
h-debate-fcc43254015Focused Ultrasound-Enhanced Antibody Delivery0.000.55APP/Aβ, tight junction proteins (claudins, occludin)proposed2026-04-29sda-2026-04-01-gap-008
h-debate-7a1478ba484Peptide Mimetics to Block Domain Interaction0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-067c9990db5Selective APOE4 Degradation and Replacement0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-083bf9f93d2Chaperone-Mediated APOE4 Refolding Therapy0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-18a83bb5a4eSmall Molecule Domain Disruptors for APOE4 Normalization0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-b4326ad0de4Allosteric Modulators Targeting Lipid Binding Enhancement0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-c417be99639Targeted Cysteine Substitution Gene Therapy0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-f75956b4a67Lipid Co-factor Supplementation Therapy0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-010
h-debate-2e6b77baccdCross-Seeding Autophagy Specificity Enhancement0.000.55SQSTM1proposed2026-04-29sda-2026-04-01-gap-011
h-debate-ff417190befGlymphatic-Autophagy Coupling Enhancement0.000.55AQP4proposed2026-04-29sda-2026-04-01-gap-011
h-debate-c0db7ae9bb4Stress Granule-Autophagy Interception Therapy0.000.55G3BP1proposed2026-04-29sda-2026-04-01-gap-011
h-debate-b3b28c95ed6Lysosomal pH Microdomains Restoration0.000.55ATP6V1Aproposed2026-04-29sda-2026-04-01-gap-011
h-debate-722e9da1535Lipid Raft Autophagy Receptor Reorganization0.000.55APOEproposed2026-04-29sda-2026-04-01-gap-011
h-debate-aff846dc0c3Retinal-Derived Neurotrophic Factor Delivery0.000.55BDNF, GDNF, TrkB, GFRα1proposed2026-04-29sda-2026-04-01-gap-012
h-debate-9168ece51e3Voice-Guided Vagal Nerve Stimulation0.000.55CHAT, α7nAChR, TNF-αproposed2026-04-29sda-2026-04-01-gap-012
h-debate-27ffadf1dcbRetinal Microvascular Neuroprotection0.000.55VEGFA, ANGPT2, CDH5proposed2026-04-29sda-2026-04-01-gap-012
h-debate-d0b38913d62Smartphone-Detected Cognitive Load Modulation0.000.55COMT, CACNA1C, GRIN2Bproposed2026-04-29sda-2026-04-01-gap-012
h-debate-c08c1a4f049Circadian-Speech Synchronization Therapy0.000.55CLOCK, BMAL1, MTNR1A/1Bproposed2026-04-29sda-2026-04-01-gap-012
h-debate-84e1e96a9c5Gait-Motor Cortex Plasticity Enhancement0.000.55BDNF, CREB1, synapsin family genesproposed2026-04-29sda-2026-04-01-gap-012
h-debate-5dfaee2f11cCircadian-Timed Senolytic Therapy0.000.55CLOCK, ARNTL, CDKN2A, CDKN1Aproposed2026-04-29sda-2026-04-01-gap-013
h-debate-e7510405c8cExtracellular Vesicle-Mediated SASP Disruption0.000.55IL1B, TNF, IL6, MIR146Aproposed2026-04-29sda-2026-04-01-gap-013
h-debate-01b2d371572Astrocyte-Specific Senolytic Delivery via GFAP-Targeted Nanoparticles0.000.55GFAP, SRC, PIK3CAproposed2026-04-29sda-2026-04-01-gap-013
h-debate-510f995a6dcMicroglial Senescence Reversal Through TREM2 Agonism0.000.55TREM2, TYROBP, SYKproposed2026-04-29sda-2026-04-01-gap-013
h-debate-2d861158748Senolytic-Primed Autophagy Enhancement0.000.55MTOR, ULK1, BCL2L1proposed2026-04-29sda-2026-04-01-gap-013
h-debate-e45b1cf8f2ep21-Targeted Proteolysis-Targeting Chimeras (PROTACs)0.000.55CDKN1Aproposed2026-04-29sda-2026-04-01-gap-013
h-debate-0d914b5bd78Dual BCL-2/CDK4/6 Inhibition for Enhanced Senolytic Efficacy0.000.55BCL2, CDK4, CDK6proposed2026-04-29sda-2026-04-01-gap-013
h-debate-5810cce4cadMitochondrial SPM Synthesis Compartmentalization0.000.55ALOX15proposed2026-04-29sda-2026-04-01-gap-014
h-debate-418a764b626Astrocyte-Microglial SPM Shuttle System Enhancement0.000.55ALOX15, GJA1proposed2026-04-29sda-2026-04-01-gap-014
h-debate-3622e2b7533Blood-Brain Barrier SPM Transporter Upregulation0.000.55SLCO1A4, SLC27A1proposed2026-04-29sda-2026-04-01-gap-014
h-debate-cb5a8619ae2Senescent Cell-Derived SPM Antagonist Neutralization0.000.55CDKN2A, TP53proposed2026-04-29sda-2026-04-01-gap-014
h-debate-4e334c6b214Microglial SPM Receptor Priming Therapy0.000.55FPR2, GPR32, GPR18proposed2026-04-29sda-2026-04-01-gap-014
4445464748
SciDEX — scidex.ai — Dashboard | Mission Control | Status | How it Works | GitHub