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Hypotheses

2,376 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-798ab8caa6eMicroglial NLRP3 Inflammasome as Circadian-Specific Drug Target0.000.55NLRP3 inflammasome / BMAL1proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-5522db93188P2Y12 Receptor-Mediated Phase Resetting of Circadian Inflammatory Rhythms0.000.55P2Y12 / BMAL1-CLOCK complexproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-d5862b41ad6Bile Acid Signaling Disruption Cascade0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-c77ea962308Prevotellaceae as Dopamine Precursor Modulators0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-8dff48967c6Circadian Rhythm Disruption via Microbiome-Clock Axis0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-2af67e4bdf2Systemic Metabolic Reprogramming via Prevotellaceae Loss0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-02154a51ed0Prevotellaceae-Mediated Enteric Nervous System Priming Theory0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-fe250a01715Immune Tolerance Breakdown via Prevotellaceae Depletion0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-d4c2b39b6fbPrevotellaceae Metabolite Depletion as Alpha-Synuclein Aggregation Catalyst0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-3f89ad537dcSynaptic Membrane Domain Stabilizers0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-8714730f4b4Membrane Fluidity Gradient Therapeutics0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-32048e06955Cholinergic-Lipid Raft Interface Modulators0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-003655d0810Synaptic Raft Rejuvenation via Ceramide Metabolism0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-147b6ec96c2APP Processing Compartmentalization Therapeutics0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-72ba8ec8205Cholesterol-Sphingolipid Ratio Modulators as Synaptic Rescuers0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-5dba64cf979Nicotinic Receptor-Lipid Raft Co-Modulators0.000.55proposed2026-04-29SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-debate-8065828c364Bi-functional Nuclear Trafficking-Phase Separation Modulators0.000.55TARDBPproposed2026-04-29sda-2026-04-01-gap-006
h-debate-07f363d7e98C-Terminal Frameshift Protection via RNA-Guided Editing0.000.55TARDBPproposed2026-04-29sda-2026-04-01-gap-006
h-debate-ca7cd06fbe9Membraneless Organelle Stabilizers Targeting Low-Complexity Domains0.000.55TARDBPproposed2026-04-29sda-2026-04-01-gap-006
h-debate-cc1a80961f9G4C2 RNA Decoy Therapeutics0.000.55C9orf72proposed2026-04-29sda-2026-04-01-gap-006
h-debate-bccf51838eaPhase Transition Kinetics Modulators0.000.55TARDBPproposed2026-04-29sda-2026-04-01-gap-006
h-debate-2bd1fc31f6eNuclear Import Receptor Enhancers as Phase Separation Modulators0.000.55TARDBPproposed2026-04-29sda-2026-04-01-gap-006
h-debate-516516c6941Arginine-Rich DPR Competitive Inhibitors0.000.55C9orf72proposed2026-04-29sda-2026-04-01-gap-006
h-debate-6024ce76e0cInnate Immunity Memory Erasure Protocol0.000.55KDM1Aproposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-73c94b586b3Synaptic Chromatin Compartment Rejuvenation0.000.55CREBBPproposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-e1f2c6598ffPartial Reprogramming with Chromatin Velocity Control0.000.55BRD4proposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-0aa85875f42Temporal Chromatin Oscillator Reset Therapy0.000.55KLF4proposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-70b72b9966dEpigenetic Clock Reversal via Metabolic Oscillator Coupling0.000.55SIRT1proposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-4e3485ffd63Metabolic-Epigenetic Coupling Restoration via ApoE Mimetics0.000.55APOEproposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-9a99b2c74b6Glial-Neuronal Epigenetic Cross-Talk Restoration0.000.55APOEproposed2026-04-29SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-c209826cba1Synthetic Biology Circuits for Network Homeostasis0.000.55Network homeostasis machineryproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-25cee9bfa90Optogenetic Control of Protein Interactions0.000.55Disease-affected interaction proteinsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-6ece528a0b9Proximity-Induced Degradation of Mislocalized Proteins0.000.55Mislocalized disease proteinsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-58f24b61f38Synthetic Compartmentalization Therapy0.000.55Compartmentalization machineryproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-8523fd7b01eRNA-Guided Subcellular Protein Targeting0.000.55Mislocalized disease proteinsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-52d41369285Chaperone-Mediated Interaction Rescue0.000.55Disease-specific interaction domainsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-4f9f0b3525bSmall Molecule Interaction Stabilizers0.000.55Multiple interaction hub proteinsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-ba7fcef7263Phase Separation Modifier Compounds0.000.55Multiple condensate proteinsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-9b9a295107bMultivalent RNA-Binding Domain Inhibitors0.000.55TP53BP1proposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-b6249bf13b7Preinitiation Complex Assembly Modulators0.000.55TBPproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-96b36f67bd3RNA Polymerase II CTD Phosphatase Modulators0.000.55POLR2Aproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-8afcc11e534RNA-Dependent Condensate Maturation Inhibitors0.000.55Multiple DDR proteinsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-e7034c03db5MRN Complex-PIC Interaction Disruptors0.000.55RAD50proposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-10550664d87Sequence-Specific RNA Antisense Oligonucleotides (ASOs) for dilncRNA Depletion0.000.55dilncRNAsproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-772daf86516RNA Aptamer-Mediated Therapeutic Condensate Hijacking0.000.5553BP1proposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-52884dbaab7Condensate Permeability Modulators for Protein Quality Control0.000.5553BP1proposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-151eb035421Multivalent Decoy Proteins for Condensate Redirection0.000.55SNCAproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-7b80773c106RNA-Guided Condensate Reprogramming for Neuroprotection0.000.5553BP1proposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-3eb94204c34Aberrant Condensate Dissolution Therapy0.000.5553BP1proposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-fbca3a2cb8eIDR Competition Therapy0.000.55MAPTproposed2026-04-29SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
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