| h-3489a7e232 | Calmodulin isoform switching from CaMK to calcineurin activation upon lysosomal | 0.61 | 0.58 | CALM1/CALM2/CALM3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| h-d3a64f5c | Correcting Gut Microbial Dopamine Imbalance to Support Systemic Dopaminergic Fun | 0.61 | 0.20 | DDC | proposed | 2026-04-03 | SDA-2026-04-01-gap-20260401-225149 |
| h-95a1adb645 | CSF ApoE- and clusterin-rich lipoprotein particles stabilize disease-relevant al | 0.61 | 0.57 | APOE | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-081644-1d2624b8-debate |
| h-9d4571a7 | Circadian-Gated Ketone Window Hypothesis | 0.61 | 0.30 | OXCT1 | proposed | 2026-04-17 | SDA-2026-04-03-gap-debate-20260403-222618-2709aad9 |
| h-722ec547 | TREM2-Mediated Microglial Checkpoint Therapy | 0.61 | 0.60 | TREM2 | proposed | 2026-04-12 | SDA-2026-04-03-gap-seaad-20260402025452 |
| h-70b7467628 | c-Abl Tyrosine Kinase Activation Drives α-Synuclein Phosphorylation and Neurodeg | 0.60 | 0.68 | ABL1 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-SDA-2026-04-26-gap | Sigma-1 Receptor-Mediated UPR Reset as Primary Disease-Modifying Mechanism of Tr | 0.60 | 0.43 | SIGMAR1, PERK/eIF2alpha axis, BiP/GRP78 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-081101-dfe3eacb |
| h-4578eac0a3 | P2RY12-mediated autophagy inhibition in cerebral VSMCs impairs CAA clearance | 0.60 | 0.68 | P2RY12 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b |
| h-4ed1b5a7 | HK2-Dependent Metabolic Checkpoint as the Gatekeeper of DAM Transition | 0.60 | 0.70 | HK2 | promoted | 2026-04-17 | SDA-2026-04-16-gap-debate-20260410-112642-fffdca96 |
| h-d949802674 | whether the Astrocyte reactivity subtypes in neurodegeneration — Rich Analysis N | 0.60 | 0.57 | Methodology | proposed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-9ab1842d |
| h-80127a2861 | whether the Mitochondrial transfer between neurons and glia — Rich Analysis Note | 0.60 | 0.57 | Methodology | proposed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-7b3b3df4 |
| h-c843352776 | TREM2 enhancement as a way to restore protective microglial response and reduce | 0.60 | 0.57 | TREM2 | proposed | 2026-04-28 | AD-MASTER-PLAN-TREM2-20260428030753 |
| h-7a3aba26c2 | APOE4 lipid dysregulation and synaptic phagocytosis as early drivers of AD patho | 0.60 | 0.57 | APOE | proposed | 2026-04-28 | AD-MASTER-PLAN-APOE-20260428030754 |
| h-3f36a225e6 | BDNF-mediated hippocampal synaptic rescue as a modifier of CA3-CA1 vulnerability | 0.60 | 0.57 | BDNF | proposed | 2026-04-28 | AD-MASTER-PLAN-BDNF-20260428030755 |
| h-51d64b2310 | GFAP-positive reactive astrocyte states as mediators of regional metabolic vulne | 0.60 | 0.57 | GFAP | proposed | 2026-04-28 | AD-MASTER-PLAN-GFAP-20260428030756 |
| h-4d0a57d392 | LRP1-mediated tau uptake disruption as an initiator of early tau propagation req | 0.60 | 0.57 | LRP1 | proposed | 2026-04-28 | AD-MASTER-PLAN-LRP1-20260428030757 |
| h-1f256c628c | microglial priming as a partially upstream causal node rather than a pure diseas | 0.60 | 0.57 | TREM2 | proposed | 2026-04-28 | SDA-2026-04-28-microglial-priming-causal-nd |
| h-13dc63ff74 | whether debate-structured causal reasoning improves calibration over direct LLM | 0.60 | 0.57 | SciDEX | proposed | 2026-04-28 | SDA-causal-benchmark-20260428-035713 |
| h-e7bcf399bb | whether the Mitochondrial transfer between neurons and glia — Rich Analysis Note | 0.60 | 0.57 | Methodology | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4 |
| h-1da06f38 | DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabili | 0.60 | 0.68 | DAPK1 | promoted | 2026-04-16 | SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d |
| h-2ff49342 | TREM2-Microglial Clearance Enhancement as Common Mechanism for Injury Prevention | 0.60 | 0.58 | TREM2 | proposed | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260410-184233-98bf553f |
| h-caa5f7e2 | Impaired TFEB/TFE3 Nuclear Translocation Due to mTORC1 Hyperactivity in Motor Ne | 0.60 | 0.65 | mTORC1-TFEB/TFE3 axis, CLEAR gene network | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| h-var-d749cd28cb | Closed-loop transcranial alternating current stimulation to restore hippocampal- | 0.60 | 0.83 | SST | promoted | 2026-04-05 | SDA-2026-04-03-26abc5e5f9f2 |
| h-86d0aa1ede | Rutin reduces ROS- and metal-driven tau oligomer nucleation | 0.60 | 0.51 | MAPT | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-085530-9015d285-debate |
| h-63a958ab | NRF2-Mediated Metabolic Reprogramming: HBOT as Direct NAMPT/SIRT1 Activator for | 0.60 | 0.62 | SIRT1 | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-181340-8acb24dc |
| h-6f30a803 | Selective TFEB Cofactor Enhancement | 0.60 | 0.40 | TFE3 | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222617-8eb5bdbc |
| h-ed960965 | STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Inte | 0.60 | 0.65 | TMEM173 (STING) | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c |
| h-4dd0d19b | LRP1-Dependent Tau Uptake Disruption | 0.60 | 0.49 | LRP1 | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-30afe4733d | TDP-43 LLPS and proteostasis dysregulation in ALS/FTD | 0.60 | 0.70 | TARDBP | proposed | 2026-04-29 | SDA-2026-04-29-gap-test-20260425-224949 |
| 738bdd16-d947-4758-b | Manual uptake test | 0.60 | 0.37 | | proposed | 2026-04-27 | |
| ea26a0a6-f96e-4918-9 | Manual uptake test | 0.60 | 0.37 | | proposed | 2026-04-27 | |
| h-SDA-2026-04-26-gap | Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Preceding Neurodegener | 0.60 | 0.34 | PDGFRB | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-e9e0225d | Neurovascular Permeability Score (NVPS): Composite Plasma + Imaging Biomarker Pa | 0.60 | 0.18 | GFAP | proposed | 2026-04-26 | SDA-2026-04-26-gap-bbb-permeability-biomarker-20260426 |
| h-6a6f132a50e9 | Activity-dependent MAP6 scaffolding at synapses | 0.60 | 0.60 | MAP6 | proposed | 2026-04-26 | paper-34025352 |
| h-5a50ce127718 | Domain boundary cross-talk hypothesis | 0.60 | 0.60 | MAP6 | proposed | 2026-04-26 | paper-40040809 |
| h-765d457dc3 | Autophagy Activation ULK1/VPS34 (H3): Lipid Routing to Lysosomes | 0.60 | 0.72 | ULK1 (autophagy initiation kinase) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-2c11c690e8 | H4: Hyperconnected Hub Status Creates Proteostatic Traffic Jams | 0.60 | 0.58 | ERN1 (IRE1α), TFG, ATG9A | proposed | 2026-04-22 | SDA-2026-04-02-gap-ec-layer2-vulnerability |
| h-5f98d0e5d4 | APOE4 Induces Region-Specific Microglial Senescence Driving Frontal Cortex Neuro | 0.60 | 0.65 | APOE4 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-9e4b98524b | mTORC1 Hyperactivation Impairs Autophagic Flux and Drives Senescence | 0.60 | 0.62 | MTOR/TFEB/TFE3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-3a5aefe1e4 | Displacement of G3BP1 RGG Box from Target RNA via Ubiquitin-Mediated Allostery | 0.60 | 0.65 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-84be6621ea | C1Q-Mediated Defective Efferocytosis Driving Necrotic Core Expansion | 0.60 | 0.55 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-af85b48c8e | TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement Cascade | 0.60 | 0.48 | TNF; TNFRSF1A; C1R; C1S | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| h-aa7eae0c3a | Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-17, blocking autopha | 0.60 | 0.65 | TARDBP | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| h-var-42a172bc53 | TREM2-Dependent Senescent Microglia Disrupt Astrocyte Communication Networks | 0.60 | 0.53 | TREM2/TYROBP | promoted | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-a09981fa01 | TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegener | 0.60 | 0.53 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-223b8be521 | TREM2-Mediated Astroglial Reactivity in Neurodegeneration | 0.60 | 0.53 | TREM2 | promoted | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-0ca9a295f6 | Rutin enhances chaperone and autophagic clearance of misfolded tau | 0.60 | 0.49 | SQSTM1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-085530-9015d285-debate |
| h-d16c2411 | Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therapy | 0.60 | 0.60 | CST, GAL3ST1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-f8316acf | Differential Interneuron Optogenetic Restoration Therapy | 0.60 | 0.70 | PVALB/SST | proposed | 2026-04-04 | SDA-2026-04-03-26abc5e5f9f2 |
| h_seaad_004 | OPC differentiation blockade contributes to white matter degeneration in early-s | 0.60 | 0.71 | PDGFRA | proposed | 2026-04-04 | SDA-2026-04-04-analysis_sea_ad_001 |