| h-9a108e26 | Pharmacological Enhancement of APOE4 Glycosylation | 0.62 | 0.58 | ST6GAL1, FUT8 | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-1e28311b | Microglial ACE Enhancement for Amyloid Clearance | 0.62 | 0.40 | ACE | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-40fbbb01 | SYNJ1 Aggregation and Solubility Loss Impairs PI(4,5)P2 Cycling at Synaptic Term | 0.62 | 0.62 | SYNJ1, INPP5A, PIK3CA, PLCG1 | proposed | 2026-04-17 | SDA-2026-04-16-gap-debate-20260411-065018-92a34465 |
| h-ee1df336 | Vagal Afferent Microbial Signal Modulation | 0.62 | 0.70 | GLP1R, BDNF | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-346639e8 | Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial deliver | 0.62 | 0.30 | TRAK1_KIF5A | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-6657f7cd | Sphingolipid Metabolism Reprogramming | 0.62 | 0.30 | CERS2 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-28c25ed899 | OPC Maturation Block via PDGFRA/LXRβ | 0.62 | 0.60 | PDGFRA | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-f0e5efbf54 | CDK5 Inhibition Blocks Activity-Dependent Tau Propagation | 0.62 | 0.68 | CDK5 | proposed | 2026-04-28 | SDA-TEST-PREREG-003 |
| h-7094b1202c | LRRK2 Kinase Inhibition Reduces α-Synuclein Spread via Lysosomal Enhancement | 0.62 | 0.75 | LRRK2 | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-8af96e9ea0 | NLRP3 Inflammasome Priming Converts SCFA-Sensitive Pyroptosis into Chronic IL-1β | 0.62 | 0.70 | NLRP3, CASP1, GSDMD, IL1B, IL1R1, C3, C1QA, GPR109A (HCAR2) | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-gwas-trem2-abi3-ph | TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD target than either l | 0.62 | 0.62 | TREM2/ABI3 | proposed | 2026-04-26 | |
| h-3a8f13ac | Senescence-Associated Epigenetic Phenotype (SEP) | 0.62 | 0.65 | Senescence-Associated Epigenetic Phenotype | proposed | 2026-04-26 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-c5dd93610a | Locus coeruleus degeneration gates whether cholinergic dysfunction or amyloid/ta | 0.62 | 0.58 | DBH, ADRB1, ADRB2 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-e849205bca |
| h-aefb475d5c | Tau fibrils expose neuronal phosphatidylserine and heat-shock protein 70, drivin | 0.62 | 0.65 | Phosphatidylserine, TIMD4, HSPA1A/HSPA1B, SCARF1, LRP8 | proposed | 2026-04-22 | SDA-2026-04-02-gap-synaptic-pruning-microglia |
| h-e8432692ff | Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulation in ALS-FTD | 0.62 | 0.20 | TARDBP, splicing targets (Sortilin1, Synaptojanin1) | proposed | 2026-04-22 | SDA-2026-04-02-gap-2026-04-01-gap-006 |
| h-5faf622cdc | Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypers | 0.62 | 0.65 | GRIN2B | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-b4e8a2f6f9 | Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 infla | 0.62 | 0.65 | CTSB | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-a93292f54f | Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift | 0.62 | 0.62 | HIF1A (HIF1α), MTOR (mTORC1), EGLN1 (PHD2) | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755 |
| h-0addc33bbe | Enhanced MCU Activity Primes mPTP Opening in Motor Neurons | 0.62 | 0.60 | MCU complex (MICU1/MICU2), mitochondrial calcium regulatory | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-9318aa358d | C1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation | 0.62 | 0.58 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-65a83ac920 | CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delivery | 0.62 | 0.72 | HDAC3 (class I histone deacetylase) | proposed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| h-a00d94b8c8 | Synaptic RNA Metabolism Dysregulation | 0.62 | 0.75 | TARDBP | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| h-b7248a5c60 | TET Enzyme-Mediated 5hmC Restoration as Neuronal Rejuvenation Strategy | 0.62 | 0.65 | TET2; TET3 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-ce92f26308 | SUV39H1 Restoration Represses Aberrant Transposon Expression in Aging Neurons | 0.62 | 0.62 | SUV39H1 (KMT1A) | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-aecdf76b | Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutam | 0.62 | 0.62 | SLC7A11 | proposed | 2026-04-17 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-a5186bb8 | H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier R | 0.62 | 0.72 | IL-22, REG3G, zonulin | promoted | 2026-04-16 | SDA-2026-04-15-gap-pubmed-20260411-093924-7330920b |
| h-a62fe64a | TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neuroprotective Phenotyp | 0.62 | 0.70 | TREM2 | promoted | 2026-04-13 | SDA-2026-04-13-gap-debate-20260411-064946-4940f331 |
| h-019c56c1 | Cross-Cell Type Synaptic Rescue via Tripartite Synapse Restoration | 0.62 | 0.65 | SYN1, SLC1A2, and CX3CR1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-bc635955 | CSF Biomarker-Guided ABCA7 Therapeutic Dosing | 0.62 | 0.70 | ABCA7 with biomarker-guided dosing | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8 |
| h-6b394be1 | Lysosomal pH Restoration Upstream of TFEB | 0.62 | 0.60 | ATP6V1A | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222617-8eb5bdbc |
| h-f811f090ac | LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target | 0.62 | 0.58 | TLR4/NFKB1/NLRP3 | proposed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| h-61196ade | TREM2-Dependent Microglial Senescence Transition | 0.62 | 0.55 | TREM2 | promoted | 2026-04-03 | SDA-BIOMNI-SCRNA_AN-248caecc |
| h-630942bd30 | PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregulat | 0.62 | 0.58 | SPP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f |
| h-c6c1143bcd | Complement Cascade Specificity: Microglial C3aR Antagonism Downstream of SPP1 | 0.62 | 0.58 | C3/C3aR | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-a01166ee | BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopamine Elevation | 0.62 | 0.45 | GCH1, TH, BH4 pathway | proposed | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-145531-5c4e7b59 |
| h-b234254c | TREM2-mediated microglial tau clearance enhancement | 0.62 | 0.52 | TREM2 | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-69d383ea | Low Complexity Domain Cross-Linking Inhibition | 0.62 | 0.30 | TGM2 | debated | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-e20cf87fb3 | LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SPP | 0.62 | 0.52 | SPP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f |
| h-8f9633d9 | Perinatal Immune Challenge Prevention | 0.62 | 0.20 | Multiple | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-ba11ca72 | NAMPT-Centered NAD+ Restoration to Reverse Basal Forebrain Cholinergic Neuron Me | 0.62 | 0.65 | NAMPT,SIRT1,PGC1A | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260411-082446-2c1c9e2d |
| h-80ff3fd6 | Spatially-Targeted Regional Vulnerability Prevention | 0.62 | 0.40 | Regional vulnerability genes | proposed | 2026-04-14 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-e8d49d4cbc | MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync | 0.61 | 0.60 | MFN2 (MFN2), PACS2 (PACS2) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-fe1dfe730e | Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradiat | 0.61 | 0.56 | PINK1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-193006-9525a13b-debate |
| h-b47073b186 | Glial-Autophagy-Senescence Coupling Defines CNS Therapeutic Windows | 0.61 | 0.55 | TFEB, MAPK14, MAPKAPK2, IL6, CXCL1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-5e85ca4f | Dose-Response Framework: PINK1/Parkin Mitophagy as the Critical Mediator Linking | 0.61 | 0.60 | PINK1 | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-181340-8acb24dc |
| h-8f285020 | Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade | 0.61 | 0.30 | AGER | proposed | 2026-04-03 | SDA-2026-04-01-gap-20260401-225149 |
| h-297a9dcbfa | FUS Mutations Alter Stress Granule Material Properties to Confer Autophagy Resis | 0.61 | 0.62 | FUS | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-3a4f2027 | Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Targeting | 0.61 | 0.50 | HTT, DMPK, repeat-containing transcripts | proposed | 2026-04-03 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-24e08335 | Restoring Neuroprotective Tryptophan Metabolism via Targeted Probiotic Engineeri | 0.61 | 0.30 | TDC | proposed | 2026-04-03 | SDA-2026-04-01-gap-20260401-225149 |
| h-50a535f9 | SIRT6-NAD+ Axis Enhancement Therapy | 0.61 | 0.30 | SIRT6 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-bc5f270e |