Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ubiquitylation-dependent turnover: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| h-gap-92152803-m1 | involves | hypothesis | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ubiquitylation-dependent turnover is the actionable driver i | 0.344 | neurodegeneration | How do ALS-linked UBQLN2 mutations affec |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.344
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Common Driver Mutations in AML: Biological Impact, Clinical Considerations, and [PMID:39195279] | Nong T, Mehra S, Taylor J | Cells | 2024 | 0 |
| Targeted therapy for lung cancer: Beyond EGFR and ALK. [PMID:37073562] | Herrera-Juárez M, Serrano-Gómez C, Bote- | Cancer | 2023 | 0 |
| UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD. [PMID:34273246] | Lin BC, Higgins NR, Phung TH | FEBS J | 2022 | 0 |
| Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alte [PMID:34985916] | Tan AC, Tan DSW | J Clin Oncol | 2022 | 0 |
| Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. [PMID:35948633] | Zingg D, Bhin J, Yemelyanenko J | Nature | 2022 | 0 |
| UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD. [PMID:34273246] | ["Lin Brian C", "Higgins Nicole R", "Phu | The FEBS journal | 2022 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Ze'ev; López-Erauskin Jone; | Nature neuroscience | 2019 | 0 |
| Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis. [PMID:30948552] | Maniatis S, Äijö T, Vickovic S, Braine C | Science (New York, N.Y.) | 2019 | 0 |
| Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis. [PMID:30948552] | Maniatis S, Äijö T, Vickovic S, Braine C | Science (New York, N.Y.) | 2019 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Z, López-Erauskin J, Baughn MW, | Nature neuroscience | 2019 | 0 |
| Human endogenous retrovirus-K contributes to motor neuron disease. [PMID:26424568] | Li W, Lee MH, Henderson L, Tyagi R, Bach | Science translational medicine | 2015 | 0 |
| Human endogenous retrovirus-K contributes to motor neuron disease. [PMID:26424568] | Li W, Lee MH, Henderson L, Tyagi R, Bach | Science translational medicine | 2015 | 0 |
| Neurotrophins and neurodegeneration. [PMID:12787319] | Dawbarn D, Allen SJ | Neuropathology and applied neu | 2003 | 0 |
| Neurotrophins and neurodegeneration. [PMID:12787319] | Dawbarn D, Allen SJ | Neuropathology and applied neu | 2003 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning ubiquitylation-dependent turnover in their description or question text
No additional research found