Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about proteasome shuttle failure: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| h-gap-92152803-m3 | involves | hypothesis | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| proteasome shuttle failure defines the therapeutic window fo | 0.723 | neurodegeneration | How do ALS-linked UBQLN2 mutations affec |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.750
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The genetics of amyotrophic lateral sclerosis. [PMID:38967083] | Nijs M, Van Damme P | Curr Opin Neurol | 2024 | 1 |
| Carnitine Shuttle and Ferroptosis in Cancer. [PMID:40867868] | Kim YA, Lee Y, Kim MS | Antioxidants (Basel) | 2025 | 0 |
| The genetics of amyotrophic lateral sclerosis. [PMID:38967083] | Nijs M, Van Damme P | Curr Opin Neurol | 2024 | 0 |
| Endogenous retroviruses are dysregulated in ALS. [PMID:38989463] | Pasternack, Doucet-O'Hare, Johnson, Paul | iScience | 2024 | 0 |
| Endogenous retroviruses are dysregulated in ALS. [PMID:38989463] | Unknown | iScience | 2024 | 0 |
| REM Sleep: An Unknown Indicator of Sleep Quality. [PMID:34948586] | Barbato G | Int J Environ Res Public Healt | 2021 | 0 |
| Diagnostic and therapeutic options in recurrent implantation failure. [PMID:32266059] | Moustafa S, Young SL | F1000Res | 2020 | 0 |
| Organ Failure Due to Systemic Injury in Acute Pancreatitis. [PMID:30768987] | Garg PK, Singh VP | Gastroenterology | 2019 | 0 |
| Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiologic [PMID:31185581] | van den Bos, Geevasinga, Higashihara, Me | International journal of molec | 2019 | 0 |
| ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now? [PMID:31866818] | Mejzini R, Flynn LL, Pitout IL | Front Neurosci | 2019 | 0 |
| Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiologic [PMID:31185581] | Unknown | International journal of molec | 2019 | 0 |
| Stress Granules and ALS: A Case of Causation or Correlation? [PMID:29916020] | Fernandes, Eshleman, Buchan | Advances in neurobiology | 2018 | 0 |
| Stress Granules and ALS: A Case of Causation or Correlation? [PMID:29916020] | Unknown | Advances in neurobiology | 2018 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 3 · Score: 0.75 · 2026-04-26
active · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning proteasome shuttle failure in their description or question text
No additional research found