Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about tau fibrils: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | associated_with | disease | 0.95 |
| Tau Inclusions | promotes | phenotype | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | component_of | protein | 0.95 |
| Heparin | binds | drug | 0.95 |
| Hsp70/Hsp40 system | disaggregates | protein | 0.90 |
| Heparan Sulfate | interacts_with | compound | 0.90 |
| TAU | aggregates_with | protein | 0.90 |
| Glycosaminoglycans | interacts_with | compound | 0.88 |
| TRIM11 | associated_with | protein | 0.85 |
| Lipofuscinosis | promotes | phenotype | 0.85 |
| lipofuscinosis | increases_accumulation_of | disease | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Tau fibrils expose neuronal phosphatidylserine and heat-shoc | 0.620 | neurodegeneration | Synaptic pruning by microglia in neurode |
Scientific analyses that reference this entity
protein folding | 2026-04-06 | 13 hypotheses Top: 0.765
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning tau fibrils in their description or question text
No additional research found