protein

VAPB-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAPB-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

VAPB Protein

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🔬 Protein Info

Gene Symbol	VAPB
Full Name	PROTEIN
Aliases	VAMP-Associated Protein B
Chromosome	20q13.33
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	33 kDa
Amino Acids	243 aa
Pathways	Immune Response
UniProt ID	O95295
NCBI Gene ID	9217
Ensembl ID	ENSG00000124194
OMIM	608627
GeneCards	VAPB
Human Protein Atlas	VAPB
Associated Diseases	Aging, Als, Amyotrophic Lateral Sclerosis, Cardiovascular, Dementia, Ms
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, FUS, LYSOSOME, MTORC1, NPC1
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VAPB-PROTEIN — AlphaFold O95255 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    A["Gene expression"] --> B["VAPB PROTEIN"]
    B --> C["Protein folding and
quality control"]
    B --> D["Cellular signaling"]
    C --> E["Proteostasis"]
    D --> F["Neurotoxicity"]
    E --> G["Disease outcome"]
    F --> G
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class B protein
    class G disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VAPB-PROTEIN in their description or question text

No additional research found