protein

CREB1-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREB1-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

CREB1 Protein

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🔬 Protein Info

Gene Symbol	CREB1
Full Name	PROTEIN
Chromosome	2q33.3
Protein Type	Transcription Factor
Function	CREB1 is a transcription factor that regulates gene expression in response to cAMP and calcium signaling.
Primary Expression	brain, with high levels in hippocampus, cortex, and striatum
Molecular Weight	37 kDa
Pathways	Apoptosis, CREB signaling, MAPK signaling, Mapk, Oxidative Phosphorylation
UniProt ID	P16220
NCBI Gene ID	1385
Ensembl ID	ENSG00000108748
OMIM	123810
GeneCards	CREB1
Human Protein Atlas	CREB1
Associated Diseases	Breast Cancer, Cancer, neurodegeneration
Interactions	ACTB, Actin, AMPK, AND, APOE, APOPTOSIS
KG Connections	242 knowledge graph edges
Databases	GeneCards HPA STRING

Pathway Diagram

graph TD
    A["Gene expression"] --> B["CREB1 PROTEIN"]
    B --> C["Protein folding and
quality control"]
    B --> D["Cellular signaling"]
    C --> E["Proteostasis"]
    D --> F["Neurotoxicity"]
    E --> G["Disease outcome"]
    F --> G
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class B protein
    class G disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CREB1-PROTEIN in their description or question text

No additional research found