Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about protective chromatin remodeling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| h-gap-456a357b-m3 | involves | hypothesis | 0.70 |
| h-gap-e7852b55-m3 | involves | hypothesis | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| protective chromatin remodeling defines the therapeutic wind | 0.723 | neurodegeneration | Are DNA methylation changes in neurodege |
| protective chromatin remodeling defines the therapeutic wind | 0.723 | neurodegeneration | Are age-related DNA methylation changes |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.750
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.750
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550] | Chappidi, Quail, Doll, Vogel, Aleksandro | Cell | 2024 | 0 |
| DNA-Origami-Armored DNA Condensates. [PMID:39075031] | Yamashita, Sato, Suzuki, Ishikawa, Takin | Chembiochem : a European journ | 2024 | 0 |
| PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550] | Unknown | Cell | 2024 | 0 |
| DNA-Origami-Armored DNA Condensates. [PMID:39075031] | Unknown | Chembiochem : a European journ | 2024 | 0 |
| Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313] | Boldinova, Makarova | Biochemistry. Biokhimiia | 2023 | 0 |
| Global identification of SWI/SNF targets reveals compensation by EP400. [PMID:37922899] | Martin BJE, Ablondi EF, Goglia C | Cell | 2023 | 0 |
| Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313] | Unknown | Biochemistry. Biokhimiia | 2023 | 0 |
| Bone remodeling: an operational process ensuring survival and bone mechanical co [PMID:35851054] | Bolamperti S, Villa I, Rubinacci A | Bone Res | 2022 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therap [PMID:32873422] | Centore RC, Sandoval GJ, Soares LMM | Trends Genet | 2020 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Homologous recombination and the repair of DNA double-strand breaks. [PMID:29599286] | Wright, Shah, Heyer | The Journal of biological chem | 2019 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Z, López-Erauskin J, Baughn MW, | Nature neuroscience | 2019 | 0 |
| Homologous recombination and the repair of DNA double-strand breaks. [PMID:29599286] | Unknown | The Journal of biological chem | 2019 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Z, López-Erauskin J, Baughn MW, | Nature neuroscience | 2019 | 0 |
| DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899] | Merlo, Cuchillo-Ibañez, Parlato, Ra | Neural plasticity | 2018 | 0 |
| Immunometabolic Pathways in BCG-Induced Trained Immunity. [PMID:27926861] | Arts RJW, Carvalho A, La Rocca C | Cell Rep | 2016 | 0 |
| DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899] | Unknown | Neural Plast | 2016 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 3 · Score: 0.75 · 2026-04-26
active · Rounds: 3 · Score: 0.75 · 2026-04-26
active · Rounds: 3 · Score: 0.75 · 2026-04-26
active · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning protective chromatin remodeling in their description or question text
No additional research found