Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about age-linked CpG drift: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| h-gap-e7852b55-m1 | involves | hypothesis | 0.70 |
| h-gap-456a357b-m1 | involves | hypothesis | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| age-linked CpG drift is the actionable driver in: Are DNA me | 0.344 | neurodegeneration | Are DNA methylation changes in neurodege |
| age-linked CpG drift is the actionable driver in: Are age-re | 0.344 | neurodegeneration | Are age-related DNA methylation changes |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.344
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.345
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740] | Hannum G, Guinney J, Zhao L, Zhang L, Hu | Mol Cell | 2013 | 1 |
| DNA methylation and prediction of biological age. [PMID:41602542] | Chen Y, Cheng X, Ji S | Front Mol Biosci | 2025 | 0 |
| Causality-enriched epigenetic age uncouples damage and adaptation. [PMID:38243142] | Ying K, Liu H, Tarkhov AE | Nat Aging | 2024 | 0 |
| Causality-enriched epigenetic age uncouples damage and adaptation. [PMID:38243142] | Ying K, Liu H, Tarkhov AE, Sadler MC, Lu | Nature aging | 2024 | 0 |
| Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive ne [PMID:36931244] | Khazaei Sima; Chen Carol C L; Andrade Au | Cell | 2023 | 0 |
| Neurodegeneration and epigenetics: A review. [PMID:37344098] | Ghosh P, Saadat A | Neurologia (Engl Ed) | 2023 | 0 |
| Neurodegeneration and epigenetics: A review. [PMID:37344098] | ["Ghosh P", "Saadat A"] | Neurologia | 2023 | 0 |
| Site-specific mitochondrial dysfunction in neurodegeneration. [PMID:35182728] | Vodičková A, Koren SA, Wojtovich AP | Mitochondrion | 2022 | 0 |
| DNA damage and repair in age-related inflammation. [PMID:35831609] | Zhao Yang; Simon Matthew; Seluanov Andre | Nature reviews. Immunology | 2022 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Nutritional Epigenomics and Age-Related Disease. [PMID:32666030] | Amenyah SD, Ward M, Strain JJ | Curr Dev Nutr | 2020 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Ze'ev; López-Erauskin Jone; | Nature neuroscience | 2019 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Z, López-Erauskin J, Baughn MW, | Nature neuroscience | 2019 | 0 |
| DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899] | Merlo, Cuchillo-Ibañez, Parlato, Ra | Neural plasticity | 2018 | 0 |
| DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899] | Unknown | Neural Plast | 2016 | 0 |
| DNA methylation and healthy human aging. [PMID:25913071] | Jones MJ, Goodman SJ, Kobor MS | Aging Cell | 2015 | 0 |
| Human endogenous retrovirus-K contributes to motor neuron disease. [PMID:26424568] | Li W, Lee MH, Henderson L, Tyagi R, Bach | Science translational medicine | 2015 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning age-linked CpG drift in their description or question text
No additional research found