Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about liproxstatin-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | inhibits | process | 0.95 |
| Apoptosis | inhibits | process | 0.90 |
| Pyroptosis | inhibits | process | 0.90 |
| Necroptosis | inhibits | process | 0.90 |
| Metabolic Dysfunction-Associated Fatty Liver Disease | treats | disease | 0.90 |
| ACSL4 | downregulates | gene | 0.85 |
| ALOX15 | downregulates | gene | 0.85 |
| Panoptosis | inhibits | process | 0.85 |
| Lipid Peroxidation | inhibits | process | 0.85 |
| Insulin Resistance | associated_with | phenotype | 0.85 |
| metabolic dysfunction-associated fatty liver disease | alleviates | disease | 0.80 |
| ALOX12/15 | inhibits | protein | 0.70 |
| BBB integrity | protects_against | phenotype | 0.70 |
| BBB integrity | protective_against | phenotype | 0.70 |
| ferroptosis | inhibits | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ACSL4 | pathway_target_of | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Liproxstatin-1 as Mechanism-Validation Tool for Ferroptosis | 0.580 | neurodegeneration | Can ferroptosis inhibitors prevent BBB d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning liproxstatin-1 in their description or question text
No additional research found