concept

BLOOD-BRAIN BARRIER DISRUPTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER DISRUPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

1Hypotheses

1Analyses

36Outgoing

46Incoming

0Experiments

1Debates

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💡 Concept Info

Name	BLOOD-BRAIN BARRIER DISRUPTION
Key Genes/Proteins	FUS, MFSD2A, VEGF
Related Diseases	NEUROINFLAMMATION, STROKE
Related Pathways	AMPK PATHWAY

Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER_DISRUPTION["BLOOD-BRAIN BARRIER DISRUPTION"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Neuroinflammation["Neuroinflammation"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Multiple_Sclerosis["Multiple Sclerosis"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Central_Nervous_System_Damage["Central Nervous System Damage"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    TREM1["TREM1"] -->|"mediates"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Sepsis["Sepsis"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Ischemic_Stroke["Ischemic Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Tight_Junctions["Tight Junctions"] -->|"involved_in"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Methamphetamine["Methamphetamine"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Stroke["Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    TREM1_Inhibition["TREM1 Inhibition"] -.protects against.-> BLOOD_BRAIN_BARRIER_DISRUPTION
    Hypoxia["Hypoxia"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION

Outgoing (36)

Target	Relation	Type	Str
Long COVID-Associated Brain Fog	causes	disease	0.95
Increased Permeability	causes	phenotype	0.95
Brain Arteriovenous Malformations	associated_with	disease	0.95
Neuroinflammation	causes	process	0.92
Stroke	contributes_to	disease	0.91
Traumatic Brain Injury	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Chronic Inflammation	contributes_to	process	0.90
Neuroinflammation	mediates	process	0.90
NEUROINFLAMMATION	causes	process	0.90
Multiple Sclerosis	associated_with	disease	0.90
Central Nervous System Diseases	contributes_to	disease	0.90
Neuroinflammation	associated_with	process	0.85
Central Nervous System Damage	causes	disease	0.85
Brain Hemorrhage	causes	disease	0.85
Neurological Sequelae	contributes_to	phenotype	0.85
Brain Injury	contributes_to	process	0.85
Glymphatic Dysfunction	exacerbates	mechanism	0.85
neurodegeneration	promotes	phenotype	0.85
Neuroinflammatory Cascades	contributes_to	process	0.85
Cognitive Impairment	causes	phenotype	0.85
Neurodegenerative Diseases	contributes_to	disease	0.85
Neurodegenerative Diseases	biomarker_for	disease	0.85
Brain Hemorrhage	contributes_to	disease	0.80
Parkinson's Disease	contributes_to	disease	0.80
neuroinflammation	promotes	process	0.80
Bleeding Risk	contributes_to	phenotype	0.80
Alzheimer's Disease	contributes_to	disease	0.75
ENDOTHELIAL CELLS	regulates	cell_type	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
EMPAGLIFLOZIN	associated_with	drug	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
AMPK PATHWAY	associated_with	pathway	0.45
WHITE MATTER	associated_with	brain_region	0.45

Incoming (46)

Source	Relation	Type	Str
Sepsis	causes	disease	0.95
Ischemic Stroke	causes	disease	0.95
Tight Junction Damage	contributes_to	mechanism	0.90
33381913	results in	paper	0.90
35361905	is a hallmark of	paper	0.90
MICROGLIA	regulates	cell_type	0.90
Tight Junctions	involved_in	process	0.90
Hypoxia	causes	process	0.90
A1AR Ablation	protects_against	mechanism	0.90
M2 Microglia-Targeting Lipid Nanoparticle	treats	drug	0.90
Stroke	causes	disease	0.90
TIGHT JUNCTION PROTEINS	mediates	protein	0.90
AQP4 Autoantibodies	causes	biomarker	0.90
Sustained Systemic Inflammation	contributes_to	process	0.90
Methamphetamine	causes	drug	0.90
TREM1 Inhibition	protects_against	mechanism	0.90
CAV1	contributes_to	protein	0.87
Autophagy Inhibition	associated_with	process	0.87
Microglia Polarization	modulates	process	0.85
Tight Junction Damage	causes	mechanism	0.85
CD40L	mediates	protein	0.85
M2 Microglia	protects_against	cell_type	0.85
Complement System	contributes_to	pathway	0.85
EXTRACELLULAR HMGB1	causes	protein	0.85
tight junctions	contributes_to	process	0.85
Complement System	promotes	pathway	0.85
APOE	involved_in	protein	0.85
CLDN5	involved_in	gene	0.85
APOE	contributes_to	protein	0.82
ZFPs	promotes	protein	0.80
CLDN5	biomarker_for	protein	0.80
COVID-19	causes	disease	0.80
mRNA nanoparticles	ameliorates	compound	0.80
AQP4	associated_with	protein	0.80
ASPARAGINE ENDOPEPTIDASE	involved_in	enzyme	0.75
neuroinflammation	activates	process	0.70
APOE4	causes	gene	0.70
EMPAGLIFLOZIN	inhibits	drug	0.65
MFSD2A	inhibits	gene	0.65
MICROGLIA	treats	cell_type	0.65
STROKE	treats	disease	0.65
STROKE	inhibits	disease	0.65
ASTROCYTE	interacts_with	cell_type	0.65
VEGF	regulates	gene	0.65
FUS	regulates	gene	0.65
AMPK	protects_against	protein	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Blood-Brain Barrier Disruption Enabling Peripheral Inflammat	0.430	neurodegeneration	How does APOE4 mechanistically increase

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.580

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract identifies APOE4 association with increased TDP-43 pathology but th

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

Related Research

Hypotheses and analyses mentioning BLOOD-BRAIN BARRIER DISRUPTION in their description or question text

No additional research found