Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ap1s1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| vesicular_transport | regulates | pathway | 0.50 |
| neurodegeneration | associated_with | disease | 0.50 |
| TNFRSF25 | co_associated_with | gene | 0.40 |
| Mitochondrial respiratory complexes and inflammatory cytokine receptors | co_associated_with | gene | 0.40 |
| CGAS, STING1 | co_associated_with | gene | 0.40 |
| CXCL10 | co_associated_with | gene | 0.40 |
| PFN1 | co_associated_with | gene | 0.40 |
| Cell-type specific vulnerability markers | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 41404470 | encodes | paper | 0.90 |
| 40954504 | is positioned as a critical aging-related gene at the nexus of | paper | 0.60 |
| 40954504 | may represent a potential therapeutic target for | paper | 0.60 |
| h-4639c944 | targets | hypothesis | 0.60 |
| aging | downregulates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| AP1S1-Mediated Vesicular Transport Restoration | 0.588 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ap1s1 in their description or question text
No additional research found