Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Vascular / VEGF signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Retinal Vascular Microcirculation Rescue | 0.718 | neurodegeneration | Digital biomarkers and AI-driven early d |
| Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat | 0.705 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Vascular mural cell degeneration precedes and exacerbates pa | 0.649 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.860
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Irisin effects on angiogenesis in human endothelial cells | exploratory | bone fracture | 0.900 | 0.00 | human umbilical vein endotheli | proposed | N/A |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Prodromal Parkinson's Disease Biomarker Development — Early Detection | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Vascular Contributions to Alzheimer Disease and Mixed Pathology | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043] | Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY | Stem Cell Res Ther | 2025 | 1 |
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152] | Kan T, He Z, Du J, Xu M, Cui J, Han X, T | J Orthop Translat | 2022 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989] | Yang H, Lee WS, Kong SJ, Kim CG, Kim JH, | J Clin Invest | 2019 | 1 |
| Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] | Keller A | Annual review of physiology | 2026 | 0 |
| Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009] | Yıldırım MA, Korkmaz S, Çelik HHA, Büyük | Cutis | 2026 | 0 |
| Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811] | Wang Y, Zhang Z, Cao L, Huang S, Huang X | J Ethnopharmacol | 2026 | 0 |
| Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710] | Yang X, Xiao JH, Li X, Liu RM, Yuan Q | J Ethnopharmacol | 2026 | 0 |
| Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296] | Maier AD, Laurentiussen CO, Michaelsen S | Acta Neuropathol Commun | 2026 | 0 |
| Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797] | Prabhudesai S, Thirugnanam K, Song X, Ya | Life Sci Alliance | 2026 | 0 |
| Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860] | Li J, Li A, Ye C, Zhang L, Jiang M et al | Mol Neurodegener | 2026 | 0 |
| FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis [PMID:41680210] | Sun F, Zhao Y, Do J, Cheng P, Li E et al | Nat Commun | 2026 | 0 |
| CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134] | Odendaal J, Fishwick K, Correia GDS, Lee | Human reproduction (Oxford, En | 2026 | 0 |
| Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] | Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu | Clinical & experimental ophtha | 2026 | 0 |
| [Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411] | Yin XY, Zhao ZH, Wang Y, Cai N, Chen S | Zhongguo dang dai er ke za zhi | 2026 | 0 |
| Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425] | Alagarasu K, Gurav YK, Pulinchani A, Bac | Journal of medical virology | 2026 | 0 |
| Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] | Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn | Pathology international | 2026 | 0 |
| Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595] | Mathis S, Putzer G, Gasteiger L, Staier | Transplant international : off | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning Vascular / VEGF signaling in their description or question text
No additional research found