Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PROTEIN_FOLDING | activates | phenotype | 0.72 |
| SYNAPTIC_FUNCTION | regulates | phenotype | 0.56 |
| APOPTOSIS | activates | phenotype | 0.56 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 5 hypotheses Top: 0.640
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice | validation | Alzheimer's disease | 0.950 | 0.00 | APP/PS1 transgenic mice (8 mon | proposed | N/A |
| Curcumin-Licorice Combination in D-galactose/Sodium Nitrite AD Model | validation | Alzheimer's disease | 0.950 | 0.00 | C57BL/6 mice | proposed | N/A |
| Irisin effects on osteogenic differentiation in mesenchymal stem cells | exploratory | bone fracture | 0.900 | 0.00 | mouse bone mesenchymal stem ce | proposed | N/A |
| SPP1 upregulation in perivascular cells in AD mouse models | exploratory | Alzheimer's disease | 0.900 | 0.00 | AD mouse models | proposed | N/A |
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study | validation | Alzheimer's disease | 0.900 | 0.00 | young APPswe/PSEN1 double-tran | proposed | N/A |
| Cerebrovascular function analysis in CD2AP mutant mice | validation | Alzheimer's disease | 0.900 | 0.00 | mice | proposed | N/A |
| Cx43 knockdown effects on mitochondrial transfer | exploratory | osteoarthritis | 0.900 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Cerebral blood flow regulation in CD2AP mutant mice | validation | Alzheimer's disease | 0.880 | 0.00 | mice | proposed | N/A |
| Abeta-induced cell death and aggregation in GD3S-deficient neurons | exploratory | Alzheimer's disease | 0.850 | 0.00 | primary neurons and astrocytes | proposed | N/A |
| Generation of Aβ-specific Tregs using CRISPR-Cas9 | exploratory | Alzheimer's disease | 0.850 | 0.00 | engineered Tregs | proposed | N/A |
| Confocal imaging of MSC-chondrocyte interactions during mitochondrial | exploratory | osteoarthritis | 0.850 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Cell-cell interaction analysis of perivascular-microglial crosstalk | exploratory | Alzheimer's disease | 0.800 | 0.00 | AD mouse models | proposed | N/A |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Vascular Contributions to Alzheimer Disease and Mixed Pathology | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Integrated multimodal cell atlas of Alzheimer’s disease [PMID:37292694] | Gabitto MI, Travaglini KJ, Rachleff VM, | Research Square | 2023 | 63 |
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. [PMID:37683629] | Zhan R, Meng X, Tian D, Xu J, Cui H, Yan | Neuron | 2023 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] | Boal AM, Risner ML, Cooper ML, Wareham L | Cells | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852] | ["Ramirez G", "Hernandez D", "Teal A", " | Research square | 2026 | 0 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven Gamze; Gezegen Haşim; & | Acta neurologica Belgica | 2026 | 0 |
| Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009] | Yıldırım MA, Korkmaz S, Çelik HHA, Büyük | Cutis | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609] | Yakati V, Rao SS | Biotechnol Bioeng | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |
| Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444] | Tan Y, Yang T, Jiang S, Li S, Cai L et a | J Inorg Biochem | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning UPR in their description or question text
Score: 0.640 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The hypothesis centers on the ten-eleven translocation 1 (TET1) enzyme's critical
Score: 0.620 · neuroinflammation · 2026-04-21
## Mechanistic Overview C1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation starts from the claim that m
Score: 0.618 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The proposed PDGF-BB/PDGFRβ/STAT3 signaling axis represents a complex intercellul
Score: 0.610 · neuroinflammation · 2026-04-22
## Mechanistic Overview Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology s
Score: 0.559 · neurodegeneration · 2026-04-02
Pharmacological enhancement of connexin-43 expression in astrocytes increases tunneling nanotube formation and mitochond
Score: 0.550 · neurodegeneration · 2026-04-25
PGE₂ signaling through EP4 receptor transcriptionally upregulates SLC7A11, enhancing cystine uptake and GSH synthesis to
Score: 0.496 · neurodegeneration · 2026-04-22
## Mechanistic Overview TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through CSF1R-Mediated
Score: 0.480 · neurodegeneration · 2026-04-21
## Mechanistic Overview Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation starts from the claim that modulat
Score: 0.460 · neurodegeneration · 2026-04-25
HBOT promotes pericyte survival via PDGF-BB/PDGFR-β signaling and upregulates claudin-5 transcription through HIF-2α to
Score: 0.450 · metabolomics · 2026-04-25
Restoration of Neuronal Ketone Body Utilization via MCT1 Upregulation
Score: 0.442 · neurodegeneration · 2026-04-22
## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts