gene

U2AF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about U2AF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

1Analyses

2Outgoing

2Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	U2AF2
Chromosome	19q13.42
Function	is a core spliceosomal protein essential for the recognition of the 3' splice site during pre-mRNA splicing.
Molecular Weight	65kDa
Amino Acids	475 aa
Pathways	pathway: Assembly Sequence:
Ensembl ID	ENSG00000163251
GeneCards	U2AF2
Human Protein Atlas	U2AF2
N-terminal RS domain	Arginine-serine repeats for protein-protein interactions
RNA recognition motif (RRM) domains	Multiple RRMs for RNA binding
Polypyrimidine tract binding region	Specific recognition element
U2AF homology motif (UHM)	Interfaces with U2AF1
Polypyrimidine tract	Stretch of 10-20 pyrimidines (U/C) preceding the splice site
3' AG dinucleotide	The absolutely conserved terminal nucleotides
Associated Diseases	Als, Ms
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

u2af2

gene · 1118 words

→

U2AF2 Protein

protein · 601 words

→

Pathway Diagram

graph TD
    U2AF2["U2AF2"]
    Als["Als"]
    Ms["Ms"]
    RBFOX1["RBFOX1"]
    neurodegeneration["neurodegeneration"]

    U2AF2 -->|"associated with"| Als
    U2AF2 -->|"associated with"| Ms
    RBFOX1 -->|"associated with"| U2AF2
    U2AF2 -->|"implicated in"| neurodegeneration

    style U2AF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Als fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style Ms fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style RBFOX1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (2)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65

Incoming (2)

Source	Relation	Type	Str
GBA intron-retained transcript	sequesters	RNA	0.00
RBFOX1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning U2AF2 in their description or question text

No additional research found