Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TFR1, LRP1, CAV1, ABCB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TFR1, LRP1, CAV1, ABCB1 |
| Key Genes/Proteins | APOE, LRP1, LDLR, AQP4, CLDN5, OCLN, FCGRT, LRP1, MTNR1A, MTNR1B, MTNR1A |
| Related Diseases | neurodegeneration |
graph TD
TFR1__LRP1__CAV1__ABCB1[TFR1, LRP1, CAV1, ABCB1]
TFR1__LRP1__CAV1__ABCB1 -->|data_in| benchmark_ot_ad_answer_key_TFR[benchmark_ot_ad_answer_key:TFR1, LRP1, CAV1, ABCB1]
LRP1__MTNR1A__MTNR1B[LRP1, MTNR1A, MTNR1B] -->|debate_co_mention| TFR1__LRP1__CAV1__ABCB1
MTNR1A[MTNR1A] -->|debate_co_mention| TFR1__LRP1__CAV1__ABCB1
OCLN[OCLN] -->|debate_co_mention| TFR1__LRP1__CAV1__ABCB1
TFR1[TFR1] -->|debate_co_mention| TFR1__LRP1__CAV1__ABCB1
AQP4[AQP4] -->|co_associated_with| TFR1__LRP1__CAV1__ABCB1
CLDN5__OCLN[CLDN5, OCLN] -->|co_associated_with| TFR1__LRP1__CAV1__ABCB1
FCGRT[FCGRT] -->|co_associated_with| TFR1__LRP1__CAV1__ABCB1
APOE__LRP1__LDLR[APOE, LRP1, LDLR] -->|co_associated_with| TFR1__LRP1__CAV1__ABCB1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:TFR1, LRP1, CAV1, ABCB1 | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:TFR1, LRP1, CAV1, ABCB1 | data_in | dataset_row | 0.00 |
| LRP1, MTNR1A, MTNR1B | debate_co_mention | gene | 0.45 |
| MTNR1A | debate_co_mention | gene | 0.45 |
| OCLN | debate_co_mention | gene | 0.45 |
| TFR1 | debate_co_mention | gene | 0.45 |
| AQP4 | co_associated_with | gene | 0.40 |
| CLDN5, OCLN | co_associated_with | gene | 0.40 |
| FCGRT | co_associated_with | gene | 0.40 |
| LRP1, MTNR1A, MTNR1B | co_associated_with | gene | 0.40 |
| TFR1 | co_associated_with | gene | 0.40 |
| APOE, LRP1, LDLR | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synthetic Biology BBB Endothelial Cell Reprogramming | 0.727 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Blood-Based Biomarker Panel for Early AD Detection | clinical | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $220,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic bas [PMID:36577758] | Gharbi Severine Isabelle; Pelletier Laur | NPJ breast cancer | 2022 | 0 |
| The biology of beauty sleep. [PMID:35256810] | Jordan A Anderson; Jenny Tung | Nature ecology & evolution | 2022 | 0 |
| Cathepsin S is a novel target for age-related dry eye. [PMID:34910926] | ["Yu Z", "Li J", "Govindarajan G", "Hamm | Experimental eye research | 2022 | 0 |
| Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867] | ["Yu K", "Niu X", "Krook-Magnuson E", "H | Nature communications | 2021 | 0 |
| Warning wristbands for patients with intra-ocular gas [PMID:31745326] | Naderi Khayam; Masoero Pietro; Karthikey | Eye | 2020 | 0 |
| NK cells for cancer immunotherapy. [PMID:31907401] | ["Shimasaki N", "Jain A", "Campana D"] | Nature reviews. Drug discovery | 2020 | 0 |
| Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636] | ["Zhou W", "Ma L", "Yang J", "Qiao H", " | Cell death & disease | 2019 | 0 |
| Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373] | ["Goswami S", "Peipert B", "Mongelli M", | Surgery | 2019 | 0 |
| Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403] | ["Zhao Y", "Zhang Z", "Gao J", "Wang P", | Cell reports | 2018 | 0 |
| Cell transplantation therapy for spinal cord injury. [PMID:28440805] | ["Assinck P", "Duncan G", "Hilton B", "P | Nature neuroscience | 2017 | 0 |
| Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. [PMID:22343897] | ["Ichimura A", "Hirasawa A", "Poulain-Go | Nature | 2012 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning TFR1, LRP1, CAV1, ABCB1 in their description or question text
No additional research found