Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP1, MTNR1A, MTNR1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LRP1, MTNR1A, MTNR1B |
| Key Genes/Proteins | APOE, LRP1, LDLR, AQP4, CLDN5, CLDN5, OCLN, FCGRT, LRP1 |
| Related Diseases | neurodegeneration |
graph TD
LRP1__MTNR1A__MTNR1B[LRP1, MTNR1A, MTNR1B]
LRP1__MTNR1A__MTNR1B -->|debate_co_mention| MTNR1A[MTNR1A]
LRP1__MTNR1A__MTNR1B -->|debate_co_mention| OCLN[OCLN]
LRP1__MTNR1A__MTNR1B -->|debate_co_mention| TFR1[TFR1]
LRP1__MTNR1A__MTNR1B -->|debate_co_mention| TFR1__LRP1__CAV1__ABCB1[TFR1, LRP1, CAV1, ABCB1]
LRP1__MTNR1A__MTNR1B -->|data_in| benchmark_ot_ad_answer_key_LRP[benchmark_ot_ad_answer_key:LRP1, MTNR1A, MTNR1B]
CLDN5[CLDN5] -->|debate_co_mention| LRP1__MTNR1A__MTNR1B
CLDN5__OCLN[CLDN5, OCLN] -->|debate_co_mention| LRP1__MTNR1A__MTNR1B
FCGRT[FCGRT] -->|debate_co_mention| LRP1__MTNR1A__MTNR1B
LRP1[LRP1] -->|debate_co_mention| LRP1__MTNR1A__MTNR1B
AQP4[AQP4] -->|co_associated_with| LRP1__MTNR1A__MTNR1B
APOE__LRP1__LDLR[APOE, LRP1, LDLR] -->|co_associated_with| LRP1__MTNR1A__MTNR1B
benchmark_ot_ad_answer_key_LRP -->|data_in| LRP1__MTNR1A__MTNR1B| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:LRP1, MTNR1A, MTNR1B | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| OCLN | debate_co_mention | gene | 0.45 |
| TFR1 | debate_co_mention | gene | 0.45 |
| MTNR1A | debate_co_mention | gene | 0.45 |
| TFR1, LRP1, CAV1, ABCB1 | debate_co_mention | gene | 0.45 |
| TFR1, LRP1, CAV1, ABCB1 | co_associated_with | gene | 0.40 |
| TFR1 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:LRP1, MTNR1A, MTNR1B | data_in | dataset_row | 0.00 |
| CLDN5 | debate_co_mention | gene | 0.45 |
| CLDN5, OCLN | debate_co_mention | gene | 0.45 |
| FCGRT | debate_co_mention | gene | 0.45 |
| LRP1 | debate_co_mention | gene | 0.45 |
| AQP4 | co_associated_with | gene | 0.40 |
| CLDN5, OCLN | co_associated_with | gene | 0.40 |
| FCGRT | co_associated_with | gene | 0.40 |
| APOE, LRP1, LDLR | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian-Synchronized LRP1 Pathway Activation | 0.714 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Blood-Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted St [PMID:38003477] | Alkhalifa AE, Al-Ghraiybah NF, Odum J, S | International journal of molec | 2023 | 0 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 0 |
| Dexamethasone and lactoferrin induced PMN-MDSCs relieved inflammatory adverse ev [PMID:33637832] | ["Li X", "Chen J", "Chen Y", "Qiao Y", " | Communications biology | 2021 | 0 |
| HMGB1/RAGE/TLR4 axis and glutamate as novel targets for PCSK9 inhibitor in high [PMID:33667517] | ["Abuelezz S", "Hendawy N"] | Life sciences | 2021 | 0 |
| Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. [PMID:33533918] | ["Nikolakopoulou A", "Wang Y", "Ma Q", " | The Journal of experimental me | 2021 | 0 |
| SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Developme [PMID:28082404] | ["Luo C", "Cheng Y", "Liu Y", "Chen L", | Cancer research | 2017 | 0 |
| Score sheets and analgesia [PMID:27909189] | Golledge Huw; Jirkof Paulin | Laboratory Animals | 2016 | 0 |
| Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endo [PMID:27262837] | ["Wang L", "Shen F", "Zhang M", "He Q", | Toxicology | 2016 | 0 |
| Frequency and factors leading to recurrent pre-eclampsia. [PMID:26564287] | Emanuel M, Butt S | JPMA. The Journal of the Pakis | 2015 | 0 |
| Esophageal motility disorders after bariatric surgery. [PMID:23852119] | Jennifer Shiroky; Brenda G Jimenez Canti | Dysphagia | 2014 | 0 |
| Enhanced transdermal bioavailability of testosterone propionate via surfactant-m [PMID:23990718] | ["Meng S", "Chen Z", "Yang L", "Zhang W" | International journal of nanom | 2013 | 0 |
| Understanding why users tag: A survey of tagging motivation literature and resul [PMID:23471473] | ["Strohmaier M", "K\u00f6rner C", "Kern | Web semantics (Online) | 2012 | 0 |
| Relationship of ventricular and atrial dilatation to valvular function in endura [PMID:19687209] | ["Prakken N", "Velthuis B", "Bosker A", | British journal of sports medi | 2011 | 0 |
| Fruit and vegetable intake in relation to risk of breast cancer in the Black Wom [PMID:20937636] | ["Boggs D", "Palmer J", "Wise L", "Spieg | American journal of epidemiolo | 2010 | 0 |
| Cannabinoids for cancer treatment: progress and promise. [PMID:18199524] | ["Sarfaraz S", "Adhami V", "Syed D", "Af | Cancer research | 2008 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning LRP1, MTNR1A, MTNR1B in their description or question text
No additional research found