gene

TAB3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TAB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for TAB3 Gene

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🧬 Gene Info

Gene Symbol	TAB3
Full Name	TAK1-Binding Protein 3
Protein Family	TAK1-binding proteins
Protein Type	Adaptor Protein
Function	TAB3 is a homolog of TAB2 that also links TAK1 to TRAF6 in NF-κB signaling.
Molecular Weight	93 kDa
Pathways	NF-κB, MAPK signaling, mapk, TGF-β, NF-κB pathway
UniProt ID	[Q9N2I8](https://www.uniprot.org/uniprot/Q9N2I8)
GeneCards	TAB3
Human Protein Atlas	TAB3
Cytokine receptors	IL-1R, IL-18R, TNF receptor superfamily
TLRs	TLR2, TLR3, TLR4, TLR9
TGF-β receptors	Type I and type II TGF-β receptors
B-cell receptors (BCR)	BCR engagement triggers TAK1 activation via TAB3
Immune system	High expression in spleen, thymus, lymph nodes, peripheral blood leucocytes
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAB3["TAB3"]
    neurodegeneration["neurodegeneration"]
    TAB3 -->|"implicated_in"| neurodegeneration
    style TAB3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TAB3 in their description or question text

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