| Gene Symbol | TAB3 |
| Full Name | TAK1-Binding Protein 3 |
| Protein Family | TAK1-binding proteins |
| Protein Type | Adaptor Protein |
| Function | TAB3 is a homolog of TAB2 that also links TAK1 to TRAF6 in NF-κB signaling. |
| Molecular Weight | 93 kDa |
| Pathways | NF-κB, MAPK signaling, mapk, TGF-β, NF-κB pathway |
| UniProt ID | [Q9N2I8](https://www.uniprot.org/uniprot/Q9N2I8) |
| GeneCards | TAB3 |
| Human Protein Atlas | TAB3 |
| Cytokine receptors | IL-1R, IL-18R, TNF receptor superfamily |
| TLRs | TLR2, TLR3, TLR4, TLR9 |
| TGF-β receptors | Type I and type II TGF-β receptors |
| B-cell receptors (BCR) | BCR engagement triggers TAK1 activation via TAB3 |
| Immune system | High expression in spleen, thymus, lymph nodes, peripheral blood leucocytes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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