Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Stress Granule: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ALS/FTD | risk_factor_for | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress | 0.810 | ALS | - |
| Stress Granule Phase Separation Modulators | 0.720 | neurodegeneration | RNA binding protein dysregulation across |
| C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra | 0.717 | neurodegeneration | How do pathological stress granules in n |
| Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic | 0.700 | neurodegeneration | How do disease-associated mutations in G |
| Differential Ubiquitin Chain Topology Creates 'Invisible' Su | 0.682 | neurodegeneration | How do pathological stress granules in n |
| TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Gr | 0.650 | Alzheimer's disease | - |
| FUS Mutations Alter Stress Granule Material Properties to Co | 0.613 | neurodegeneration | How do pathological stress granules in n |
| FUS Mutations Impede G3BP1's Chaperone Function, Exposing Ne | 0.430 | neurodegeneration | How do disease-associated mutations in G |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.712
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730
neurodegeneration | 2026-04-06 | 8 hypotheses Top: 0.856
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.700
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| G3BP1-mediated stress granule assembly via liquid-liquid phase separat | exploratory | 0.900 | 0.00 | eukaryotic cells | proposed | N/A | |
| TRIM21 E3 ubiquitin ligase screen for stress granule regulation | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells | proposed | N/A |
| G3BP1 intrinsically disordered region analysis and phosphorylation eff | exploratory | 0.850 | 0.00 | in vitro protein analysis syst | proposed | N/A | |
| G3BP1-binding factor cooperativity in stress granule network regulatio | exploratory | 0.800 | 0.00 | cell culture systems with prot | proposed | N/A | |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Multiscale Computational Modeling of Protein Aggregation Kinetics | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Pre-Symptomatic Detection and Intervention Timing in Genetic Prion Dis | validation | ALS | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Protein Aggregation Kinetic Validation Results | validation | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $120,000 |
| Stress Granule Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] | Yang P, Mathieu C, Kolaitis RM, Zhang P, | Cell | 2020 | 3 |
| LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation Wit [PMID:40693377] | Wang Y, Yin L, Zheng S, Liu A, Liu C, Ba | Hypertension | 2025 | 1 |
| The important role of stress granules in prostate cancer development, progressio [PMID:40972860] | Xu Z, You H, Gu J, Jiang J, Yan Z, Jin X | Gene | 2025 | 1 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] | Gwon Y, Maxwell BA, Kolaitis RM, Zhang P | Science | 2021 | 1 |
| STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183] | Eom E, Kim J, Kim J, Kang SJ | Cell death and differentiation | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | ["Desai M", "Gulati K", "Agrawal M", "Gh | Neural regeneration research | 2026 | 0 |
| WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747] | Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li | Proceedings of the National Ac | 2026 | 0 |
| NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201] | Sun H, Yang C, Du J, Xu C, Chen Y, Chen | Cell death & disease | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Translational neurodegeneratio | 2026 | 0 |
| Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932] | Mulloy RP, Evseev D, Sharlin N, Bui-Mari | PLoS biology | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | Desai M, Gulati K, Agrawal M, Ghumra S, | Neural Regen Res | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Transl Neurodegener | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Front Pharmacol | 2026 | 0 |
| Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190] | Akbarin MM, Farjami Z, Álvarez HR | Mol Biol Rep | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Frontiers in pharmacology | 2026 | 0 |
| Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration. [PMID:40014573] | ["Sahoo P", "Agrawal M", "Hanovice N", " | Proceedings of the National Ac | 2025 | 0 |
| RIOK1 phase separation restricts PTEN translation via stress granules activating [PMID:40467995] | ["Meng F", "Li H", "Huang Y", "Wang C", | Nature cancer | 2025 | 0 |
| β-propeller protein-associated neurodegeneration protein WDR45 regulates stress [PMID:40473629] | ["Li Y", "Fang J", "Ding Y", "Zhang X", | Nature communications | 2025 | 0 |
| Identification of small molecule inhibitors of G3BP-driven stress granule format [PMID:38284934] | ["Freibaum B", "Messing J", "Nakamura H" | The Journal of cell biology | 2024 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.58 · 2026-04-27
closed · Rounds: 4 · Score: 0.69 · 2026-04-22
closed · Rounds: 4 · Score: 0.84 · 2026-04-22
closed · Rounds: 4 · Score: 0.79 · 2026-04-21
closed · Rounds: 4 · Score: 0.76 · 2026-04-21
Hypotheses and analyses mentioning Stress Granule in their description or question text
Score: 0.613 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The fundamental molecular mechanism underlying this hypothesis centers on the abe
Score: 0.430 · neurodegeneration · 2026-04-22
## Mechanistic Overview FUS Mutations Impede G3BP1's Chaperone Function, Exposing Neurotoxic Stress Granule Intermediate