Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLEEP DISTURBANCES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SLEEP DISTURBANCES |
graph TD
SLEEP_DISTURBANCES[SLEEP DISTURBANCES]
SLEEP_DISTURBANCES -->|causes| Glymphatic_dysfunction[Glymphatic dysfunction]
SLEEP_DISTURBANCES -->|activates| Neuroinflammation[Neuroinflammation]
SLEEP_DISTURBANCES -->|causes| Neuroprotection_Deficit[Neuroprotection Deficit]
SLEEP_DISTURBANCES -->|risk_factor_for| Alzheimer_s_Disease[Alzheimer's Disease]
Alzheimer_s_Disease -->|causes| SLEEP_DISTURBANCES
APP[APP] -->|causes| SLEEP_DISTURBANCES
HCRTR1[HCRTR1] -->|regulates| SLEEP_DISTURBANCES| Target | Relation | Type | Str |
|---|---|---|---|
| Glymphatic dysfunction | causes | phenotype | 0.90 |
| Alzheimer's Disease | associated_with | disease | 0.90 |
| Neuroinflammation | activates | process | 0.85 |
| Neuroprotection Deficit | causes | process | 0.80 |
| Alzheimer'S Disease | associated_with | disease | 0.80 |
| Oxidative Stress | associated_with | process | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | causes | disease | 0.93 |
| 36868636 | correlate with | paper | 0.90 |
| Mood Disorders | associated_with | disease | 0.90 |
| 41579208 | are closely associated with | paper | 0.90 |
| 41579208 | affects | paper | 0.90 |
| APP | causes | gene | 0.88 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Idiopathic Normal Pressure Hydrocephalus | associated_with | disease | 0.85 |
| 36868636 | have a bidirectional relationship with | paper | 0.60 |
| HCRTR1 | regulates | gene | 0.60 |
| 41579208 | associated with | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLEEP DISTURBANCES in their description or question text
No additional research found