| Gene Symbol | ent-gene-28e2cb01 |
| Extracellular domain | Immunoglobulin-like V-type domain for ligand binding |
| Transmembrane domain | Single pass membrane spanning region |
| Intracellular tail | Short cytoplasmic domain lacking known signaling motifs |
| Soluble TREM2 (sTREM2) | Proteolytically shedded ectodomain detectable in cerebrospinal fluid |
| Microglia | Primary expressing cell type in the brain |
| Macrophages | Peripheral immune cells with similar functions |
| Osteoclasts | Bone-resorbing cells where TREM2 was originally discovered |
| Dendritic cells | Antigen-presenting cells in peripheral immune system |
| Apolipoprotein E (ApoE) | High-affinity TREM2 ligand |
| Ph phosphatidylserine (PS) | "Eat me" signal on apoptotic cells |
| Phospholipids | PI, cardiolipin from damaged membranes |
| Cholesterol/Fatty Acids | Metabolic state indicators |
| Amyloid-beta (Aβ) | Direct binding to aggregates |
| TREM2-L | Putative unidentified brain ligand |
| Heat Shock Proteins | Released from stressed cells |
| KG Connections | 94 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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