Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ST6GAL1, FUT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ST6GAL1, FUT8 | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ST6GAL1, FUT8 | data_in | dataset_row | 0.00 |
| APOE | debate_co_mention | gene | 0.45 |
| DNAJB1 | debate_co_mention | gene | 0.45 |
| FKBP5 | debate_co_mention | gene | 0.45 |
| HSP90AA1 | debate_co_mention | gene | 0.45 |
| HSPA1A | debate_co_mention | gene | 0.45 |
| HSPA1A, HSP90AA1, DNAJB1, FKBP5 | debate_co_mention | gene | 0.45 |
| APOE | co_associated_with | gene | 0.40 |
| HSPA1A, HSP90AA1, DNAJB1, FKBP5 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pharmacological Enhancement of APOE4 Glycosylation | 0.622 | neurodegeneration | APOE4 structural biology and therapeutic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Genetic regulation of post-translational modification of two distinct proteins. [PMID:35332118] | Landini A, Trbojević-Akmačić I, Navarro | Nat Commun | 2022 | 1 |
| Divergent Golgi trafficking limits B cell-mediated IgG sialylation. [PMID:35726710] | Glendenning LM, Zhou JY, Reynero KM, Cob | J Leukoc Biol | 2022 | 1 |
| Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotei [PMID:32141499] | Huang G, Li Z, Li Y, Liu G, Sun S, Gu J, | Biochem J | 2020 | 1 |
| Disease-associated glycans on cell surface proteins. [PMID:27131428] | Takahashi M, Kizuka Y, Ohtsubo K, Gu J, | Mol Aspects Med | 2016 | 1 |
| Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/ [PMID:35089466] | Takahashi M, Hasegawa Y, Maeda K, Kitano | Glycoconjugate journal | 2022 | 0 |
| On unproductive joy [PMID:33608365] | Elizabeth Niedra | Canadian family physician Mede | 2021 | 0 |
| Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liv [PMID:33883138] | Mathur B, Shajahan A, Arif W, Chen Q, Ha | Science advances | 2021 | 0 |
| Monolithic optical microlithography of high-density elastic circuits. [PMID:34210882] | ["Zheng Y", "Liu Y", "Zhong D", "Nikzad | Science (New York, N.Y.) | 2021 | 0 |
| STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer [PMID:32483388] | ["Arwert E", "Milford E", "Rullan A", "D | Nature cell biology | 2020 | 0 |
| An in vitro model maintaining taxon-specific functional activities of the gut mi [PMID:31515476] | ["Li L", "Abou-Samra E", "Ning Z", "Zhan | Nature communications | 2019 | 0 |
| A novel genotype of “ <i>Anaplasma capra</i> ” in wildlife and its phylogenetic [PMID:30538218] | Jifei Yang; Zhijie Liu; Qingli Niu; Muha | Emerging microbes & infect | 2018 | 0 |
| Recurrent computations for visual pattern completion. [PMID:30104363] | ["Tang H", "Schrimpf M", "Lotter W", "Mo | Proceedings of the National Ac | 2018 | 0 |
| Altered paracellular cation permeability due to a rare CLDN10B variant causes an [PMID:28686597] | ["Klar J", "Piontek J", "Milatz S", "Tar | PLoS genetics | 2017 | 0 |
| An evolutionary perspective on cell migration: Digging for the roots of amoeboid [PMID:28539388] | ["Titus M", "Goodson H"] | The Journal of cell biology | 2017 | 0 |
| The crystal structure of a voltage-gated sodium channel. [PMID:21743477] | ["Payandeh J", "Scheuer T", "Zheng N", " | Nature | 2011 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ST6GAL1, FUT8 in their description or question text
No additional research found