Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPA1A, HSP90AA1, DNAJB1, FKBP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HSPA1A, HSP90AA1, DNAJB1, FKBP5 | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| ST6GAL1, FUT8 | debate_co_mention | gene | 0.45 |
| ST6GAL1, FUT8 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Chaperone-Mediated APOE4 Refolding Enhancement | 0.680 | neurodegeneration | APOE4 structural biology and therapeutic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Biochemical binding assays measuring PROTAC selectivity for APO | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| s:** - Dose-response studies showing therapeutic window without toxici | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| ApoE4 Function in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $360,000 |
| Down Syndrome Alzheimer's Disease: Mechanisms and Therapeutic Timing | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Metal Ion Homeostasis Dysregulation in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620] | Ding N, Song Y, Zhang Y, Yu W, Li X et a | Autophagy | 2025 | 0 |
| Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620] | Ding N, Song Y, Zhang Y, Yu W, Li X, Li | Autophagy | 2025 | 0 |
| Single nucleus RNA sequencing profile analysis to reveal cell type specific comm [PMID:40715263] | Pappu MAA, Alamin M, Sultana MH | Sci Rep | 2025 | 0 |
| Downregulation of NEAT1 due to loss of TDP-43 function exacerbates motor neuron [PMID:40661327] | Kawakami Y, Iguchi Y, Li J | Brain Commun | 2025 | 0 |
| Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel target [PMID:40319428] | ["Mohamed R", "Abdallah D", "El-Abhar H" | Inflammopharmacology | 2025 | 0 |
| Magnetothermal-activated gene editing strategy for enhanced tumor cell apoptosis [PMID:39080645] | ["Li M", "Li S", "Guo Y", "Hu P", "Shi J | Journal of nanobiotechnology | 2024 | 0 |
| Integrating network pharmacology and drug side-effect data to explore mechanism [PMID:38308871] | ["Tang M", "Wu Z", "Li F"] | Computers in biology and medic | 2024 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Curr Neuropharmacol | 2022 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Current neuropharmacology | 2022 | 0 |
| Transcriptome Analysis of Rat Lungs Exposed to Moxa Smoke after Acute Toxicity T [PMID:34961819] | ["Xu X", "Deng W", "Zhang W", "Zhang J", | Evidence-based complementary a | 2021 | 0 |
| YAP-Dependent BiP Induction Is Involved in Nicotine-Mediated Oral Cancer Maligna [PMID:34440849] | ["Chien C", "Chen Y", "Hsu C", "Chou Y", | Cells | 2021 | 0 |
| HSPA8 knock-down induces the accumulation of neurodegenerative disorder-associat [PMID:32712350] | ["Sirtori R", "Riva C", "Ferrarese C", " | Neuroscience letters | 2020 | 0 |
| Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in [PMID:32289328] | ["Upadhya R", "Zingg W", "Shetty S", "Sh | Journal of controlled release | 2020 | 0 |
| Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and C [PMID:30883359] | ["Orr A", "Kim C", "Jimenez-Morales D", | Journal of Alzheimer's disease | 2019 | 0 |
| Clinical efficiency and safety of Hsp90 inhibitor Novobiocin in avian tibial dys [PMID:30004119] | ["Nabi F", "Iqbal M", "Zhang H", "Rehman | Journal of veterinary pharmaco | 2018 | 0 |
| Chaperone-Mediated Autophagy Promotes Beclin1 Degradation in Persistently Infect [PMID:30075149] | ["Aydin Y", "Stephens C", "Chava S", "He | The American journal of pathol | 2018 | 0 |
| Results from phase II trial of HSP90 inhibitor, STA-9090 (ganetespib), in metast [PMID:30211813] | ["Shah S", "Luke J", "Jacene H", "Chen T | Melanoma research | 2018 | 0 |
| Re-examining HSPC1 inhibitors. [PMID:28255900] | Lee SL, Dempsey-Hibbert NC, Vimalachandr | Cell stress & chaperones | 2017 | 0 |
| Pharmacological Chaperones: Design and Development of New Therapeutic Strategies [PMID:27097127] | ["Convertino M", "Das J", "Dokholyan N"] | ACS chemical biology | 2016 | 0 |
| Exploring off-targets and off-systems for adverse drug reactions via chemical-pr [PMID:21483481] | ["Yang L", "Wang K", "Chen J", "Jegga A" | PLoS computational biology | 2011 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning HSPA1A, HSP90AA1, DNAJB1, FKBP5 in their description or question text
No additional research found