gene

SPG20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPG20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

12Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for SPG20 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SPG20
Full Name	Spartin
Chromosome	13q13.3
Function	is a gene encoding a protein involved in intracellular trafficking, mitochondrial function, and endosomal sorting.
Amino Acids	754 aa
Pathways	Lysosomal Membrane Permeabilization
UniProt ID	Q9GZI6
NCBI Gene ID	23111
Ensembl ID	ENSG00000133104
OMIM	275900
GeneCards	SPG20
Human Protein Atlas	SPG20
Associated Diseases	Neurodegeneration
Interactions	LYSOSOME
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPG20 — AlphaFold Q9GZI6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPG20 Gene

gene · 952 words

→

SPG20 Protein

protein · 1254 words

→

Pathway Diagram

flowchart TD
    N0["SPG20"]
    N1["Lysosomal Membrane Permeabilization"]
    N0 -->|"involved in"| N1
    N2["IST1"]
    N0 -->|"binds"| N2
    N3["ITCH"]
    N0 -->|"associated with"| N3
    N0 -->|"activates"| N3
    N4["Lipid-Packing Defects"]
    N0 -->|"associated with"| N4
    N5["Neurodegeneration"]
    N0 -->|"associated with"| N5
    N6["UBIQUITIN"]
    N0 -->|"activates"| N6
    N7["AND"]
    N0 -->|"associated with"| N7
    N8["Autophagy"]
    N0 -->|"associated with"| N8
    N9["LYSOSOME"]
    N0 -->|"associated with"| N9
    N10["NEURODEGENERATION"]
    N0 -->|"associated with"| N10
    N11["Rb"]
    N0 -->|"associated with"| N11
    N10 -->|"associated with"| N0
    N9 -->|"associated with"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 protein
    class N4 mechanism
    class N5 disease
    class N7 gene
    class N8 pathway
    class N9 gene
    class N10 gene
    class N11 protein

Outgoing (12)

Target	Relation	Type	Str
Lysosomal Membrane Permeabilization	involved_in	process	0.95
IST1	binds	protein	0.95
Lipid-Packing Defects	associated_with	mechanism	0.95
Neurodegeneration	associated_with	disease	0.85
LYSOSOME	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
UBIQUITIN	activates	entity	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Rb	associated_with	protein	0.60
NEURODEGENERATION	associated_with	gene	0.60
LYSOSOME	interacts_with	gene	0.50
LYSOSOME	activates	gene	0.50

Incoming (3)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	entity	0.60
LYSOSOME	associated_with	gene	0.60
Neurodegeneration	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPG20 in their description or question text

No additional research found