Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC31A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC31A2 |
| Full Name | Solute Carrier Family 3 Member 1A2 (SLC31A2) |
| Chromosome | 9q32 |
| Primary Expression | various tissues and plays complementary roles in copper acquisition, particularly in tissues where CTR1 expression is low or under conditions of high |
| UniProt ID | O15432 |
| NCBI Gene ID | 10552 |
| Ensembl ID | ENSG00000137573 |
| OMIM | 603086 |
| GeneCards | SLC31A2 |
| Human Protein Atlas | SLC31A2 |
| CTR1 | Dominates copper uptake at low extracellular copper concentrations |
| CTR2 | Becomes more important when copper concentrations are elevated [@affinity] |
| Associated Diseases | Als, Atherosclerosis |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["SLC31A2"]
N1["Als"]
N0 -->|"associated with"| N1
N2["Atherosclerosis"]
N0 -->|"associated with"| N2
N3["RAB23"]
N0 -->|"associated with"| N3
N4["CDKN2A"]
N0 -->|"regulates"| N4
N5["GLS"]
N0 -->|"regulates"| N5
N6["Actin"]
N0 -->|"associated with"| N6
N7["SGCE"]
N7 -->|"associated with"| N0
N8["NLRP3"]
N8 -->|"regulates"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 gene
class N6 protein
class N7 gene
class N8 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC31A2 in their description or question text
No additional research found