gene

SETDB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SETDB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

8Outgoing

3Incoming

0Experiments

0Debates

Summary

SETDB1

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🧬 Gene Info

Gene Symbol	SETDB1
Full Name	SET Domain Bifurcated Histone Lysine Methyltransferase 1
Chromosome	1q21.3
Protein Type	Transferase
Function	encodes a histone H3 lysine 9 (H3K9) methyltransferase that catalyzes mono-, di-, and trimethylation of H3K9.
UniProt ID	Q15047
Ensembl ID	ENSG00000143379
OMIM	604396
GeneCards	SETDB1
Human Protein Atlas	SETDB1
Associated Diseases	Leukemia
Interactions	AND, CGAS-STING
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SETDB1 — AlphaFold Q15047 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SETDB1

gene · 1072 words

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Pathway Diagram

graph TD
    SETDB1["SETDB1"]
    Leukemia{"Leukemia"}
    SETDB1 -->|"associated_with"| Leukemia
    Cancer{"Cancer"}
    SETDB1 -->|"therapeutic_target"| Cancer
    Infection{"Infection"}
    SETDB1 -->|"inhibits"| Infection
    Proteasome(["Proteasome"])
    SETDB1 -->|"associated_with"| Proteasome
    Epigenetic(["Epigenetic"])
    SETDB1 -->|"associated_with"| Epigenetic
    CGAS_STING["CGAS-STING"]
    SETDB1 -->|"activates"| CGAS_STING
    Stem_Cell["Stem Cell"]
    SETDB1 -->|"regulates"| Stem_Cell
    Macrophage["Macrophage"]
    SETDB1 -->|"expressed_in"| Macrophage
    CANCER["CANCER"]
    CANCER -->|"therapeutic_target"| SETDB1
    DNA["DNA"]
    DNA -->|"associated_with"| SETDB1
    AND["AND"]
    AND -->|"activates"| SETDB1
    neurodegeneration["neurodegeneration"]
    SETDB1 -->|"implicated_in"| neurodegeneration

Outgoing (8)

Target	Relation	Type	Str
Infection	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Leukemia	associated_with	disease	0.65
Proteasome	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
CGAS-STING	activates	gene	0.60
Stem Cell	regulates	cell_type	0.60
Macrophage	expressed_in	cell_type	0.60

Incoming (3)

Source	Relation	Type	Str
AND	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SETDB1 in their description or question text

No additional research found