protein

SAP97PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SAP97PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Synapse-Associated Protein 97 (SAP97), encoded by the DLG1 gene, is a 102 kDa postsynaptic scaffolding protein and a founding member of the Membrane-Associated Guanylate Kinase (MAGUK) family[@kim2007].

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🔬 Protein Info

Gene Symbol	SAP97PROTEIN
Chromosome	3q29
Protein Type	Receptor
Function	is a 102 kDa postsynaptic scaffolding protein and a founding member of the Membrane-Associated Guanylate Kinase (MAGUK) family[@kim2007].
Subcellular Localization	</strong></td><td>Postsynaptic density, Cytoplasm, Nucleus</td></tr>
Molecular Weight	102 kDa
GeneCards	SAP97PROTEIN
Human Protein Atlas	SAP97PROTEIN
PDZ domains (1-3)	Bind C-terminal motifs of transmembrane proteins including glutamate receptors, ion channels, and cell adhesion molecules. PDZ1 and PDZ2 are canonical; PDZ3 has distinctive binding preferences
SH3 domain	Proline-rich region involved in protein-protein interactions, recruits signaling molecules
Guanylate Kinase (GK) domain	Homologous to metabolic guanylate kinases but has lost catalytic activity; serves as a protein interaction module instead
AKAP79/150 complex	SAP97 recruits the A-kinase anchoring protein AKAP79/150, which brings PKA, calcineurin, and AC9 to the PSD
G-protein signaling	SAP97 interacts with G-protein subunits, modulating second messenger pathways
Cytoskeletal regulation	Through various interactors, SAP97 links synaptic receptors to the actin cytoskeleton
Associated Diseases	schizophrenia
Interactions	GluA1, MAP1B, PSD-95
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Synapse-Associated Protein 97

protein · 1135 words

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Pathway Diagram

graph TD
    SAP97PROTEIN["SAP97PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SAP97PROTEIN -->|"implicated_in"| neurodegeneration
    style SAP97PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning SAP97PROTEIN in their description or question text

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