| Gene Symbol | SAP97PROTEIN |
| Chromosome | 3q29 |
| Protein Type | Receptor |
| Function | is a 102 kDa postsynaptic scaffolding protein and a founding member of the Membrane-Associated Guanylate Kinase (MAGUK) family[@kim2007]. |
| Subcellular Localization | </strong></td><td>Postsynaptic density, Cytoplasm, Nucleus</td></tr> |
| Molecular Weight | 102 kDa |
| GeneCards | SAP97PROTEIN |
| Human Protein Atlas | SAP97PROTEIN |
| PDZ domains (1-3) | Bind C-terminal motifs of transmembrane proteins including glutamate receptors, ion channels, and cell adhesion molecules. PDZ1 and PDZ2 are canonical; PDZ3 has distinctive binding preferences |
| SH3 domain | Proline-rich region involved in protein-protein interactions, recruits signaling molecules |
| Guanylate Kinase (GK) domain | Homologous to metabolic guanylate kinases but has lost catalytic activity; serves as a protein interaction module instead |
| AKAP79/150 complex | SAP97 recruits the A-kinase anchoring protein AKAP79/150, which brings PKA, calcineurin, and AC9 to the PSD |
| G-protein signaling | SAP97 interacts with G-protein subunits, modulating second messenger pathways |
| Cytoskeletal regulation | Through various interactors, SAP97 links synaptic receptors to the actin cytoskeleton |
| Associated Diseases | schizophrenia |
| Interactions | GluA1, MAP1B, PSD-95 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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