Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SACS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SACS |
| Function | encodes a very large multidomain protein involved in protein quality control and mitochondrial dynamics. |
| Molecular Weight | 520 kDa |
| Amino Acids | 579 aa |
| Ensembl ID | ENSG00000151835 |
| GeneCards | SACS |
| Human Protein Atlas | SACS |
| Protein folding | SRR domains assist in folding/refolding of client proteins, analogous to Hsp90 |
| Protein quality control | Participates in ubiquitin-proteasome-mediated degradation of misfolded substrates |
| DnaJ domain | The J-domain recruits Hsp70 chaperones to facilitate substrate processing |
| HEPN domain | C-terminal higher eukaryotes and prokaryotes nucleotide-binding domain with potential nuclease function |
| Mitochondrial fission | Promotes DRP1-mediated mitochondrial fission |
| Network morphology | Loss of sacsin causes hyperfused, elongated mitochondrial networks |
| Mitophagy | Required for efficient clearance of damaged mitochondria |
| Respiratory chain | Sacsin-deficient cells show impaired oxidative phosphorylation |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SACS["SACS"]
Ms["Ms"]
MIRO1["MIRO1"]
MIRO2["MIRO2"]
neurodegeneration["neurodegeneration"]
SACS -->|"activates"| Ms
MIRO1 -->|"associated with"| SACS
MIRO2 -->|"associated with"| SACS
SACS -->|"implicated in"| neurodegeneration
style SACS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Ms fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
style MIRO1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style MIRO2 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SACS in their description or question text
No additional research found