gene

RPS27

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS27: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

2Outgoing

5Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RPS27
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	84 aa
Ensembl ID	ENSG00000177951
GeneCards	RPS27
Human Protein Atlas	RPS27
40S subunit assembly	Critical for proper ribosome biogenesis
mRNA binding	Facilitates mRNA binding to the small ribosomal subunit
Translation initiation	Part of the eIF2/EIF2B complex that initiates translation
p53 activation	The RPS27-MDM2-p53 axis is critical for tumor suppression and cellular stress response
Diamond-Blackfan Anemia (DBA)	RPS19 and RPS24 mutations cause ribosomal stress
5q- syndrome	Deletion of ribosomal protein genes causes bone marrow failure
Neurodevelopmental disorders	Mutations in ribosomal proteins cause intellectual disability
Ribosomal RNA (rRNA) processing defects	Observed in sporadic ALS
Ribosomal protein alterations	Changes in RPS6 and RPS10 in ALS motor neurons
Associated Diseases	neurodegeneration
Interactions	RPL35, RPL38, RPS10, RPS16, RPS28, TARDBP
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

rps27

gene · 1310 words

→

Pathway Diagram

graph TD
    RPS27["RPS27"]
    Ms{"Ms"}
    RPS27 -->|"regulates"| Ms
    RPL38["RPL38"]
    RPS27 -->|"interacts with"| RPL38
    neurodegeneration["neurodegeneration"]
    RPS27 -->|"implicated in"| neurodegeneration
    RPS28["RPS28"]
    RPS28 -->|"interacts with"| RPS27
    RPL35["RPL35"]
    RPL35 -->|"interacts with"| RPS27
    TARDBP["TARDBP"]
    TARDBP -->|"interacts with"| RPS27
    RPS10["RPS10"]
    RPS10 -->|"interacts with"| RPS27
    RPS16["RPS16"]
    RPS16 -->|"interacts with"| RPS27
    style RPS27 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
RPL38	interacts_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
RPS28	interacts_with	gene	0.60
RPL35	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
RPS10	interacts_with	gene	0.60
RPS16	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPS27 in their description or question text

No additional research found