Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPL35 |
| Full Name | Ribosomal Protein L35 |
| Chromosome | 9p22.1 |
| Function | RPL35 is a ribosomal protein component of the 60S large ribosomal subunit. |
| Amino Acids | 110 aa |
| UniProt ID | P42766 |
| NCBI Gene ID | 11224 |
| Ensembl ID | ENSG00000197603 |
| OMIM | 604157 |
| GeneCards | RPL35 |
| Human Protein Atlas | RPL35 |
| Protein synthesis | As part of the 60S subunit, RPL35 participates in the peptidyl transferase activity during protein translation |
| Ribosome assembly | RPL35 is required for proper 60S subunit biogenesis |
| Translation termination | The protein contributes to the release of the nascent polypeptide from the ribosome |
| Associated Diseases | neurodegeneration |
| Interactions | RPL38, RPS10, RPS16, RPS27, RPS28, TARDBP |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RPL35["RPL35"]
Ms{"Ms"}
RPL35 -->|"regulates"| Ms
TARDBP["TARDBP"]
RPL35 -->|"interacts with"| TARDBP
RPS10["RPS10"]
RPL35 -->|"interacts with"| RPS10
RPS16["RPS16"]
RPL35 -->|"interacts with"| RPS16
RPS27["RPS27"]
RPL35 -->|"interacts with"| RPS27
RPL38["RPL38"]
RPL35 -->|"interacts with"| RPL38
neurodegeneration["neurodegeneration"]
RPL35 -->|"implicated in"| neurodegeneration
RPS28["RPS28"]
RPS28 -->|"interacts with"| RPL35
style RPL35 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| RPS28 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPL35 in their description or question text
No additional research found