protein

RAMP1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAMP1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The RAMP family consists of three members (RAMP1, RAMP2, and RAMP3) that each confer distinct pharmacology when co-expressed with either the calcitonin receptor (CALCR) or the calcitonin receptor-like receptor (CALCRL).

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🔬 Protein Info

Gene Symbol	RAMP1PROTEIN
Chromosome	2q36.1
Function	is a single-pass membrane protein that is essential for forming functional calcitonin gene-related peptide (CGRP) receptors.
Primary Expression	various tissues, with highest levels in the trigeminal ganglion, dorsal root ganglia, and specific brain regions
Subcellular Localization	** \| Plasma membrane, Endoplasmic reticulum \|
Amino Acids	175 aa
Exons	4
GeneCards	RAMP1PROTEIN
Human Protein Atlas	RAMP1PROTEIN
N-linked glycosylation	Essential for proper folding, trafficking, and function
Disulfide bond formation	Required for structural integrity
Palmitoylation	Possible at cysteine residues near the transmembrane domain
Dimerization	RAMP1 can form homodimers, though the functional significance is unclear
Associated Diseases	Als, Alzheimer, Atherosclerosis
Interactions	Bdnf, BDNF, CREB1, CRH, CRHR1, FKBP5
KG Connections	59 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ramp1-protein

protein · 2063 words

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Pathway Diagram

graph TD
    RAMP1PROTEIN["RAMP1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RAMP1PROTEIN -->|"implicated_in"| neurodegeneration
    style RAMP1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RAMP1PROTEIN in their description or question text

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