Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RAB25 |
| Chromosome | 1q22. |
| Protein Type | Gene |
| Function | is a gene/protein involved in various cellular processes relevant to neurodegenerative diseases. |
| Primary Expression | various tissues with highest expression in: - Kidney (high expression in tubular epithelial cells) - Liver (hepatocytes) - Brain (moderate expression |
| Molecular Weight | 24 kDa |
| Amino Acids | 219 aa |
| Exons | 7 |
| GeneCards | RAB25 |
| Human Protein Atlas | RAB25 |
| Prenylation | C-terminal geranylgeranylation is essential for membrane association |
| Phosphorylation | Multiple serine/threonine phosphorylation sites identified |
| Ubiquitination | Regulates protein stability and localization |
| Polarized trafficking | Regulates transport in epithelial cells, particularly apical membrane delivery and polarized sorting |
| Lysosomal function | Controls trafficking to lysosomes and late endosomes, influencing lysosomal positioning and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["RAB25"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAB25 in their description or question text
No additional research found