protein

PTAU181

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTAU181: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	PTAU181
Chromosome	17q21
GeneCards	PTAU181
Human Protein Atlas	PTAU181
CDK5 (Cyclin-Dependent Kinase 5)	Neuron-specific kinase activated in AD
Japanese cohorts	AUC 0.89-0.93 for AD vs. controls [@japanese2022]
Chinese cohorts	AUC 0.87-0.92, with similar cutoff values to Western populations [@chinese2023]
Korean cohorts	AUC 0.90-0.95, p-tau 181 successfully distinguishes AD from MCI [@korean2023]
Associated Diseases	Alzheimer's Disease, CSF, ALS
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Phosphorylated Tau 181 (p-tau 181)

biomarker · 2950 words

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Pathway Diagram

graph TD
    PTAU181["PTAU181"]
    TAU["TAU"]
    TAU -->|"phosphorylates"| PTAU181
    PTAU181 -->|"associated_with"| TAU
    CSF["CSF"]
    PTAU181 -->|"associated_with"| CSF
    CA1["CA1"]
    PTAU181 -->|"associated_with"| CA1
    TDP_43["TDP-43"]
    PTAU181 -->|"associated_with"| TDP_43
    SOD1["SOD1"]
    PTAU181 -->|"associated_with"| SOD1
    ALS["ALS"]
    PTAU181 -->|"associated_with"| ALS
    SNAP25["SNAP25"]
    PTAU181 -->|"associated_with"| SNAP25
    TAU_PHOSPHORYLATION["TAU PHOSPHORYLATION"]
    TAU_PHOSPHORYLATION -->|"associated_with"| PTAU181
    CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
    CEREBROSPINAL_FLUID -->|"associated_with"| PTAU181
    style PTAU181 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
Alzheimer's Disease	biomarker_for	disease	0.90

Incoming (1)

Source	Relation	Type	Str
Amino acid metabolism	associated_with	pathway	0.72

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTAU181 in their description or question text

No additional research found