Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PROTEIN ARGININE METHYLTRANSFERASES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PROTEIN ARGININE METHYLTRANSFERASES |
graph TD
PROTEIN_ARGININE_METHYLTRANSFE[PROTEIN ARGININE METHYLTRANSFERASES]
PROTEIN_ARGININE_METHYLTRANSFE -->|modulates| Anti_Cancer_Drug_Resistance[Anti-Cancer Drug Resistance]
PROTEIN_ARGININE_METHYLTRANSFE -->|mediates| Epigenetic_Arginine_Methylatio[Epigenetic Arginine Methylation]
PROTEIN_ARGININE_METHYLTRANSFE -->|contributes to| Cancer_Treatment_Resistance[Cancer Treatment Resistance]
PROTEIN_ARGININE_METHYLTRANSFE -->|involved_in| Drug_Resistance[Drug Resistance]
PROTEIN_ARGININE_METHYLTRANSFE -->|modulates| Cancer_Drug_Resistance[Cancer Drug Resistance]
PROTEIN_ARGININE_METHYLTRANSFE -->|catalyzes| METHYLATION[METHYLATION]
PROTEIN_ARGININE_METHYLTRANSFE -->|mediates| Arginine_Methylation[Arginine Methylation]
PROTEIN_ARGININE_METHYLTRANSFE -->|regulates| transcription[transcription]
Small_Molecules_Targeting_Prmt[Small Molecules Targeting Prmt] -->|inhibits| PROTEIN_ARGININE_METHYLTRANSFE
Small_Molecules_Targeting_PRMT[Small Molecules Targeting PRMTs] -->|inhibits| PROTEIN_ARGININE_METHYLTRANSFE| Target | Relation | Type | Str |
|---|---|---|---|
| Anti-Cancer Drug Resistance | modulates | phenotype | 0.95 |
| Epigenetic Arginine Methylation | mediates | process | 0.95 |
| Anti-Cancer Drug Resistance | targets | phenotype | 0.95 |
| Cancer Treatment Resistance | contributes_to | disease | 0.93 |
| Drug Resistance | involved_in | phenotype | 0.92 |
| Epigenetic Arginine Methylation | regulates | process | 0.90 |
| METHYLATION | catalyzes | process | 0.90 |
| Cancer Drug Resistance | modulates | process | 0.90 |
| Cancer Treatment Resistance | involved_in | disease | 0.90 |
| Rna Biology | regulates | process | 0.90 |
| Dna Damage Response | regulates | process | 0.90 |
| Arginine Methylation | mediates | process | 0.90 |
| transcription | regulates | process | 0.90 |
| splicing | regulates | process | 0.90 |
| Cell Metabolism | regulates | process | 0.90 |
| epigenetic regulation | involved_in | process | 0.85 |
| Oncology Therapeutic Targets | associated_with | biomarker | 0.85 |
| cancer | associated_with | disease | 0.80 |
| Immune Cells | regulates | cell | 0.80 |
| Cardiovascular Function | regulates | process | 0.80 |
| Neuronal Function | regulates | process | 0.80 |
| Cancer Drug Resistance | associated_with | disease | 0.80 |
| Anti-cancer Drug Resistance | modulates | mechanism | 0.70 |
| Anti-cancer drug resistance | overcomes | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Small Molecules Targeting Prmt | inhibits | drug | 0.88 |
| Small Molecules Targeting PRMTs | inhibits | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PROTEIN ARGININE METHYLTRANSFERASES in their description or question text
No additional research found