Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about METHYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| HPA Axis | regulates | pathway | 0.90 |
| HPA AXIS RELATED GENES | modulates | gene | 0.90 |
| Epigenomic Reconfiguration | component_of | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PROTEIN ARGININE METHYLTRANSFERASES | catalyzes | enzyme | 0.90 |
| C9orf72 Repeat Expansion | associated_with | biomarker | 0.90 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| MAPK pathway inhibition by QTJD through butyrate mechanism | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | Mouse macrophages | proposed | N/A |
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study | validation | Alzheimer's disease | 0.900 | 0.00 | young APPswe/PSEN1 double-tran | proposed | N/A |
| Network pharmacology screening of ginger targets against gastric cance | exploratory | gastric cancer | 0.900 | 0.00 | computational analysis using h | proposed | N/A |
| Tet2 expression analysis in aged 2×Tg-AD mouse brains | exploratory | Alzheimer's disease | 0.850 | 0.00 | APPswe/PSEN1 double-transgenic | proposed | N/A |
| Molecular docking validation of ginger-PRMT1 interactions | exploratory | gastric cancer | 0.800 | 0.00 | computational molecular dockin | proposed | N/A |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | completed | $450,000 |
| DNA Damage Repair Deficiency Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | completed | $7,500,000 |
| Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar | validation | Neurodegeneration | 0.400 | 0.50 | human | completed | $3,000,000 |
| Epigenetic Dysregulation Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo | validation | Parkinson's Disease | 0.400 | 0.50 | human | completed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibi [PMID:40446574] | Chen G, Gou B, Du Y, Zhou Z, Bai Y, Yang | Phytomedicine | 2025 | 1 |
| PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. [PMID:38460517] | Ku B, Eisenbarth D, Baek S, Jeong TK, Ka | Cell Rep Med | 2024 | 1 |
| PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemor [PMID:38383964] | Yamamoto T, Hayashida T, Masugi Y, Oshik | Cancer Res | 2024 | 1 |
| Promising role of protein arginine methyltransferases in overcoming anti-cancer [PMID:37980859] | Zhu Y, Xia T, Chen DQ, Xiong X, Shi L, Z | Drug Resist Updat | 2024 | 1 |
| Protein arginine methylation: from enigmatic functions to therapeutic targeting. [PMID:33742187] | Wu Q, Schapira M, Arrowsmith CH, Barsyte | Nat Rev Drug Discov | 2021 | 1 |
| SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264] | Turner JS, Kim W, Kalaidina E, Goss CW, | Res Sq | 2020 | 1 |
| Reply to Rosen: Temperature-growth relationship is robust. [PMID:31375623] | Diffenbaugh NS, Burke M | Proc Natl Acad Sci U S A | 2019 | 1 |
| Cryo-electron microscopy structures of human oligosaccharyltransferase complexes [PMID:31831667] | Ramírez AS, Kowal J, Locher KP | Science | 2019 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with [PMID:28068668] | Britschgi A, Duss S, Kim S, Couto JP, Br | Nature | 2017 | 1 |
| CD161 defines a transcriptional and functional phenotype across distinct human T [PMID:25437561] | Fergusson JR, Smith KE, Fleming VM, Rajo | Cell Rep | 2014 | 1 |
| Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740] | Hannum G, Guinney J, Zhao L, Zhang L, Hu | Mol Cell | 2013 | 1 |
| Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389] | Liu K, Hong Y, Gao Q, Huang J, Liu L, Li | Cellular and molecular life sc | 2026 | 0 |
| Repression of PRMT activities sensitize human homologous recombination-proficien [PMID:41632514] | ["Zhang Y", "Xu M", "Yuan J", "Hu Z", "J | eLife | 2026 | 0 |
| IRG1-itaconate axis in immunometabolism: mechanistic roles and therapeutic poten [PMID:41743716] | Liu Y, Zhang P, Kong W, Li J, Yang H, Ba | Frontiers in immunology | 2026 | 0 |
| Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepa [PMID:41501793] | ["Wang Y", "Yuan H", "Yu Y", "Gou X", "W | Journal of translational medic | 2026 | 0 |
| DNA Methylation in the Ovary and Uterus of Mammalian Animal Models: Implications [PMID:41751612] | Serej O, Kowalik MK, Rekawiecki R | Genes | 2026 | 0 |
| Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty [PMID:41360204] | Lin ZH, Chou PI, Chang JW, Lin ZC, Sun Y | J Nutr Biochem | 2026 | 0 |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therap [PMID:41928257] | Jeong Y, Cho Y, Kim YK | J Biomed Sci | 2026 | 0 |
| Tet2-driven clonal hematopoiesis drives aortic aneurysm via macrophage-to-osteoc [PMID:41739588] | Yonekawa J, Yura Y, Luo J, Kato K, Ikeda | The Journal of clinical invest | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning METHYLATION in their description or question text
Score: 0.640 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The hypothesis centers on the ten-eleven translocation 1 (TET1) enzyme's critical
Score: 0.576 · developmental neurobiology · 2026-04-21
**Molecular Mechanism and Rationale** The proposed hypothesis centers on the epigenetic silencing of TREM2 (Triggering
Score: 0.510 · neurodegeneration · 2026-04-22
## Mechanistic Overview Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprotective Klotho Exp
Score: 0.480 · neurodegeneration · 2026-04-25
DNA Methylation Clock Drift at Glial Promoters
Score: 0.460 · neurodegeneration · 2026-04-21
## Mechanistic Overview DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targets starts from
Score: 0.440 · neurodegeneration · 2026-04-21
## Mechanistic Overview DNA Hypomethylation at P2RY12 Promoter Correlates with Disease Progression starts from the claim
Score: 0.400 · neurodegeneration · 2026-04-22
## Mechanistic Overview Small-Molecule Modulation of G3BP1 Condensate Dynamics via PRMT1 Methylation as a Therapeutic St
Score: 0.380 · neurodegeneration · 2026-04-25
DNMT1 Downregulation to Correct Genome-Wide Hypomethylation
Score: 0.350 · neurodegeneration · 2026-04-25
TET Enzyme Enhancement to Prevent Aberrant DNA Methylation
Score: 0.347 · unknown disease · 2026-04-25
Concise Statement: Progressive failure of autophagy flux in AD neurons produces a cascading epigenetic feedback loop —
Score: 0.345 · neurodegeneration · 2026-04-26
The same signal may be beneficial early and damaging late. Testing protective chromatin remodeling with single-cell meth
Score: 0.344 · neurodegeneration · 2026-04-26
The gap can be tested by treating age-linked CpG drift as an upstream driver rather than a passive correlate. If true, p
Score: 0.344 · neurodegeneration · 2026-04-26
The gap can be tested by treating age-linked CpG drift as an upstream driver rather than a passive correlate. If true, p
Score: 0.342 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada
Score: 0.327 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada