gene

PTPRN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTPRN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for PTPRN2 — Protein Tyrosine Phosphatase Receptor Type N2

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🧬 Gene Info

Gene Symbol	PTPRN2
Full Name	PTPRN2 — Protein Tyrosine Phosphatase Receptor Type N2
Chromosome	7q36.3
Protein Type	Gene
Function	It regulates the phosphorylation state of synaptic proteins including: - NMDA receptor subunits - AMPA receptor trafficking proteins - Postsynaptic density scaffolds (PSD-95, PSD-93)
Primary Expression	neuroendocrine cells and neurons
Molecular Weight	130 kDa
Pathways	MAPK, PI3K
GeneCards	PTPRN2
Human Protein Atlas	PTPRN2
Extracellular domain	Contains a tandem repeat of fibronectin type III domains involved in cell-cell adhesion and signaling
Single transmembrane helix	Anchors the protein to the plasma membrane
Brain	Cerebral cortex, hippocampus, cerebellum, and basal ganglia
Neuroendocrine tissues	Pancreatic islets, adrenal medulla, pituitary gland
Peripheral nervous system	Sensory and autonomic ganglia
Associated Diseases	Glioblastoma, Ms
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PTPRN2 — Protein Tyrosine Phosphatase Receptor Type N2

gene · 833 words

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PTPRN2 Protein

protein · 959 words

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Pathway Diagram

graph TD
    PTPRN2["PTPRN2"]
    Ms{"Ms"}
    PTPRN2 -->|"associated with"| Ms
    Glioblastoma{"Glioblastoma"}
    PTPRN2 -->|"associated with"| Glioblastoma
    DNAJC30["DNAJC30"]
    PTPRN2 -->|"associated with"| DNAJC30
    GBM["GBM"]
    PTPRN2 -->|"associated with"| GBM
    CTSD["CTSD"]
    PTPRN2 -->|"associated with"| CTSD
    neurodegeneration["neurodegeneration"]
    PTPRN2 -->|"implicated in"| neurodegeneration
    style PTPRN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
DNAJC30	associated_with	gene	0.60
GBM	associated_with	gene	0.60
CTSD	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTPRN2 in their description or question text

No additional research found